(S)-2-氨基-3-邻甲苯丙酸乙酯合成路线 （共 11 条）
反应条件
1: With lithium hydroxide monohydrate in ethanol; water T=25°C; 48 h; 2: With hydrogenchloride in ethanol; water pH=2; optical yield given as percent ee;
参考文献
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.
Organic Letters, 2009 , vol. 11, # 4 p. 807 - 810
反应条件
10 Pd/C; hydrogen in ethanol
T=20°C;
参考文献
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.
Organic Letters, 2009 , vol. 11, # 4 p. 807 - 810
反应条件
hydrogenchloride in water
3 h; Heating;
参考文献
Wu, Zhong-Liu; Li, Zu-Yi
Tetrahedron Asymmetry, 2003 , vol. 14, # 15 p. 2133 - 2142
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
1.) -78 deg C, 0.5 h, 2.) -78 deg C, 0.5 h; room temperature, overnight; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Antonov, Dmitri Yu.; Belokon, Yuri N.; Ikonnikov, Nikolai S.; Orlova, Svetlana A.; Pisarevsky, Aleksander P.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 14 p. 1873 - 1880
反应条件
1: 1) LDA / 1) THF, -78 deg C, 30 min, 2) -25 deg C, 14 h
2: 1) diphenylphosphoryl azide, NEt3 / 1) benzene, reflux, 2 h, 2) reflux, 20 h
3: KOH, 18-crown-6 / 24 h / Heating
4: HCl / 15 h / Heating
View Scheme
参考文献
Ihara, Masataka; Takahashi, Masanobu; Taniguchi, Nobuaki; Yasui, Ken; Niitsuma, Hiroko; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 3 p. 525 - 535
反应条件
1: 1) diphenylphosphoryl azide, NEt3 / 1) benzene, reflux, 2 h, 2) reflux, 20 h
2: KOH, 18-crown-6 / 24 h / Heating
3: HCl / 15 h / Heating
View Scheme
参考文献
Ihara, Masataka; Takahashi, Masanobu; Taniguchi, Nobuaki; Yasui, Ken; Niitsuma, Hiroko; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 3 p. 525 - 535
反应条件
1: 1) LDA / 1) THF, -78 deg C, 45 min, 2) -78 deg C, 2 h
2: 1) diphenylphosphoryl azide, NEt3 / 1) benzene, reflux, 2 h, 2) reflux, 20 h
3: KOH, 18-crown-6 / 24 h / Heating
4: HCl / 15 h / Heating
View Scheme
参考文献
Ihara, Masataka; Takahashi, Masanobu; Taniguchi, Nobuaki; Yasui, Ken; Niitsuma, Hiroko; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 3 p. 525 - 535
反应条件
1: KOH, 18-crown-6 / 24 h / Heating
2: HCl / 15 h / Heating
View Scheme
参考文献
Ihara, Masataka; Takahashi, Masanobu; Taniguchi, Nobuaki; Yasui, Ken; Niitsuma, Hiroko; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 3 p. 525 - 535
反应条件
hydrogenchloride
15 h; Heating;
参考文献
Ihara, Masataka; Takahashi, Masanobu; Taniguchi, Nobuaki; Yasui, Ken; Niitsuma, Hiroko; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 3 p. 525 - 535
反应条件
phosphate buffer; Humicola amino esterase
Ambient temperature; Title compound not separated from byproducts;
参考文献
Liu, Weiguo; Ray, Paul; Benezra, Steven A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 5 p. 553 - 560
