1: Rongalit; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / |Inert atmosphere 2: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / |Inert atmosphere 3: potassium carbonate / tetrahydrofuran / 48 h / |Reflux View Scheme

1: Rongalit; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / |Inert atmosphere 2: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / |Inert atmosphere View Scheme

Rongalit; sodium hydroxide in 1,4-dioxane T=55 - 60°C; 0.5 h; Inert atmosphere;

sodium hydride in N,N-dimethyl-formamide T=0 - 20°C;

sodium hydroxide in tetrahydrofuran; diethyl ether

1: 64 percent / n-butyl lithium / diethyl ether / -78 °C 2: 50 percent / aq. KOH / toluene / 20 °C View Scheme

phosphate buffer; epoxide hydrolase from Aspergillus niger in dimethyl sulfoxide T=27°C; pH=7; 4.75 h;

Aspergillus niger epoxide hydrolase in water; dimethyl sulfoxide T=27°C; 2 h;