2-硝基-4,6-二甲基苯胺合成路线 （共 25 条）
反应条件
1.1: NaNO2; conc. H2SO4 / acetic acid / 15 - 75 °C
1.2: 69 percent / aq. KI; urea
2.1: 84 percent / Cu / dimethylformamide / Heating
View Scheme
参考文献
Schmid, Rudolf; Cereghetti, Marco; Heiser, Bernd; Schoenholzer, Peter; Hansen, Hans-Juergen
Helvetica Chimica Acta, 1988 , vol. 71, p. 897 - 930
反应条件
1: With hydrogen bromide in water
0.166667 h; Reflux;
2: With sodium nitrite in water
T=0°C; 0.5 h;
3: With copper(I) bromide in water
T=20°C; 3.5 h; Reflux;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; LAWSON, John David; SABAT, Mark; SMITH, Christopher; WANG, Haixia; CHEN, Young K.; KANOUNI, Toufike
Patent: WO2013/148603 A1, 2013 ;
Location in patent: Paragraph 0176-0177 ;
反应条件
1: hydrogenchloride; sodium nitrite; copper (I) cyanide; acetic acid / water / 7.5 h / 0 - 20 °C
2: N,N-dimethyl acetamide / 14 h / |Reflux
View Scheme
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald
Patent: US2013/281397 A1, 2013 ;
反应条件
(i) NaNO2, aq. H2SO4, (ii) /BRN= 3587244/; Multistep reaction;
参考文献
Andrews,B.D. et al.
Australian Journal of Chemistry, 1972 , vol. 25, p. 639 - 646
反应条件
1: With sulfuric acid; sodium nitrite in acetic acid
T=15 - 75°C;
2: With urea; potassium iodide
参考文献
Liang, Yuxue; Gao, Shuang; Wan, Huihui; Wang, Junwei; Chen, Huilin; Zheng, Zhuo; Hu, Xinquan
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1267 - 1273
