(2S,3S,5S)-2-(N,N-二苄基氨基)-3-羟基-5-(叔-丁基氧羰基氨基)-1,6-二苯基己烷合成路线 （共 9 条）
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3101 - 3103
反应条件
hydrogenchloride; sodium hydroxide; potassium hydrogensulfate; lithium aluminium tetrahydride; KBH4 in tetrahydrofuran; methanol; dichloromethane
反应条件
1: (5S)-2-amino-5-dibenzylamino-4-oxo-1,6-diphenylhex-2-ene With sodium tetrahydroborate; acetic acid in tetrahydrofuran T=20°C; 3.5 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C; 4 h; 3: With sodium tetrahydroborate in tetrahydrofuran; methanol T=20°C; 0.5 h;
参考文献
Organic Process Research and Development, , vol. 3, # 2 p. 94 - 100
反应条件
1.1: potassium carbonate; potassium hydroxide / water / 5 h / |Reflux 2.1: sodium amide / acetonitrile; tert-butyl methyl ether / 2 h / 0 - 5 °C / |Large scale 2.2: 2 h / 25 °C / |Large scale 3.1: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 3.5 h / 20 °C 3.2: 4 h / 20 °C 3.3: 0.5 h / 20 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 3, # 2 p. 94 - 100
反应条件
1.1: sodium amide / acetonitrile; tert-butyl methyl ether / 2 h / 0 - 5 °C / |Large scale 1.2: 2 h / 25 °C / |Large scale 2.1: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 3.5 h / 20 °C 2.2: 4 h / 20 °C 2.3: 0.5 h / 20 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 3, # 2 p. 94 - 100
反应条件
palladium dihydroxide; ammonium formate
参考文献
Abbott Laboratories
Patent: EP1170289 A2, 2002 ;
Location in patent: Page 40 ;
反应条件
1: Pd(OH)2; HCO2NH4 2: EDC 3: trifluoroacetic acid View Scheme
参考文献
Sham, Hing L.; Zhao, Chen; Li, Leping; Betebenner, David A.; Saldivar, Ayda; Vasavanonda, Sudthida; Kempf, Dale J.; Plattner, Jacob J.; Norbeck, Daniel W.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3101 - 3103
反应条件
1: Pd(OH)2; HCO2NH4 2: EDC 3: trifluoroacetic acid View Scheme
参考文献
Sham, Hing L.; Zhao, Chen; Li, Leping; Betebenner, David A.; Saldivar, Ayda; Vasavanonda, Sudthida; Kempf, Dale J.; Plattner, Jacob J.; Norbeck, Daniel W.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3101 - 3103
反应条件
1: Pd(OH)2; HCO2NH4 2: EDC View Scheme
参考文献
Sham, Hing L.; Zhao, Chen; Li, Leping; Betebenner, David A.; Saldivar, Ayda; Vasavanonda, Sudthida; Kempf, Dale J.; Plattner, Jacob J.; Norbeck, Daniel W.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3101 - 3103
