(Z)-2-甲基戊-2-烯酸合成路线 （共 6 条）
反应条件
T=220°C; durch Destillation;
参考文献
Lucas; Prater
Journal of the American Chemical Society, 1937 , vol. 59, p. 1684
反应条件
1: concentrated HCl
2: 220 °C / durch Destillation
View Scheme
参考文献
Lucas; Prater
Journal of the American Chemical Society, 1937 , vol. 59, p. 1684
反应条件
potassium hydroxide in methanol
2 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Palaty; Abbott
Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3398 - 3406
反应条件
1: 100 percent / Br2 / CH2Cl2 / 1 h / -78 °C
2: 83 percent / sodium bicarbonate / dimethylformamide / 0.58 h / 65 °C
3: 1.) t-BuLi / 1) ether, pentane, -78 deg C, 40 min; 2) ether, pentane, -78 to -20 deg C
View Scheme
参考文献
Kim, Heejin; Lee, Suk-Kwan; Lee, Dongreyoul; Cha, Jin Kun
Synthetic Communications, 1998 , vol. 28, # 4 p. 729 - 735
反应条件
tert.-butyl lithium
1) ether, pentane, -78 deg C, 40 min; 2) ether, pentane, -78 to -20 deg C; Yield given. Multistep reaction;
参考文献
Kim, Heejin; Lee, Suk-Kwan; Lee, Dongreyoul; Cha, Jin Kun
Synthetic Communications, 1998 , vol. 28, # 4 p. 729 - 735
反应条件
1: (i) aq. H2SO4, (ii) aq. HCl
2: 260 °C
View Scheme
参考文献
Bergel'son,L.D. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1962 , p. 1525 - 1529
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1962 , # 9 p. 1612 - 1617
