2: LiAlH4 / diethyl ether / Heating 3: Py*HClCrO3 View Scheme

2: LiAlH4 / diethyl ether / Heating View Scheme

N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium hexamethyldisilazane 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

P=1900 - 2280 Torr; Hydrogenation;

N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium hexamethyldisilazane 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

1: 89.7 percent / NaH, Me2SO / 24 h / Ambient temperature 2: 79.6 percent / H2 / Pd/C / ethyl acetate / 4 h / 760 Torr / Ambient temperature View Scheme

sodium hydride; dimethyl sulfoxide 24 h; Ambient temperature;

<b>Multi-step reaction with 3 steps<br /> </b>1: 79.1 percent / n-BuLi / tetrahydrofuran; hexane / 1) -78 deg C, 10 min 2) r.t., 90 min<br />2: 47.5 percent / H₂SO₄ conc. / 18 h / Heating<br />3: 96 percent / CrO₃, pyridine / CH₂Cl₂ / 0.33 h<br /> <br /> &nbsp;

&nbsp;(i) O₃, (ii) Ph₃P;&nbsp;&nbsp;Multistep reaction;&nbsp;<br /> &nbsp;