2-氨基-3-甲基吡啶合成路线 （共 128 条）
反应条件
potassium hydroxide in pyridine; ethanol; water
参考文献
Kabi Pharmacia AB
Patent: US5302718 A1, 1994 ;
反应条件
sulfuric acid; sodium carbonate; sodium nitrite in ethanol; water
参考文献
Sankyo Company, Limited
Patent: US5541317 A1, 1996 ;
参考文献
Merck Frosst Canada, Inc.
Patent: US5698584 A1, 1997 ;
反应条件
1: H2SO4; HNO3 2: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 3: phosphoryl chloride 4: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation 5: ethyl nitrite / Erwaermen des erhaltenen Diazoniumsalzes mit Petrolaether 6: KMnO4; H2O View Scheme
参考文献
Hawkins; Roe
Journal of Organic Chemistry, 1949 , vol. 14, p. 328,331
反应条件
[bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate in tetrahydrofuran T=7°C; 2 h;
参考文献
Wang, Xianpei; Ma, Lijuan; Yu, Wei
Synthesis, 2011 , # 15 p. 2445 - 2453
参考文献
Di Chiacchio; Rimoli; Avallone; Arena; Abignente; Filippelli; Falcone
Archiv der Pharmazie, 1998 , vol. 331, # 9 p. 273 - 278
反应条件
1: NaNO2, aq. H2SO4 2: P2S5 / 160 °C View Scheme
参考文献
Hirai, Koichi; Iwano, Yuji; Mikoshiba, Isamu; Koyama, Hiroo; Nishi, Takahide
Heterocycles, 1994 , vol. 38, # 2 p. 277 - 280
反应条件
1: in ethanol 5 h; Heating / reflux; 2: With sodium hydrogencarbonate in ethanol; water
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: WO2005/68432 A1, 2005 ;
Location in patent: Page/Page column 201 ;
反应条件
sulfuric acid; nitric acid
参考文献
Seide
Chemische Berichte, 1924 , vol. 57, p. 1804
Chemische Berichte, 1925 , vol. 58, p. 1733
反应条件
1: 22 percent / ethanol / 1.5 h / Heating 2: 50 percent / cyclohexadiene / Pd/C / ethanol / 2 h / Heating View Scheme
参考文献
Shah, Chandra; McAtee, Laura; Breitenbucher, J Guy; Rudolph, Dale; Li, Xiaobing; Lovenberg, Timothy W; Mazur, Curt; Wilson, Sandy J; Carruthers, Nicholas I
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 22 p. 3309 - 3312
