2-氨基-3-甲基吡啶合成路线 （共 128 条）
反应条件
copper(I) oxide; potassium carbonate; ammonium hydroxide; N,N-dimethylethylenediamine in ethylene glycol T=60°C; 16 h; Inert atmosphere;
参考文献
Elmkaddem, Mohammed K.; Fischmeister, Cedric; Thomas, Christophe M.; Renaud, Jean-Luc
Chemical Communications, 2010 , vol. 46, # 6 p. 925 - 927
反应条件
diphenyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; diphenyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H58NO4PPdS; C50H58NO4PPdS; ammonia; sodium t-butanolate in 1,4-dioxane T=50°C; 24 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 15, # 14 p. 3734 - 3737
反应条件
1: With p-methylbenzenesulfonyl (tosylate); tert-butylamine in various solvent(s) 0.25 h; 2: With trifluoroacetic acid in various solvent(s) T=70°C; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 72, # 12 p. 4554 - 4557
反应条件
bis(η3-allyl-μ-chloropalladium(II)); 2-(di-1-adamantylphosphino)-N,N-dimethylaniline; ammonia; sodium t-butanolate in 1,4-dioxane T=110 - 120°C; Buchwald-Hartwig amination; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 16, # 6 p. 1983 - 1991
反应条件
sodium amide; xylene T=135 - 140°C;
参考文献
Chemische Berichte, , vol. 57, p. 1804
Chemische Berichte, , vol. 58, p. 1733
反应条件
1: CH2Cl2 / Heating 2: conc. HCl View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 10, # 17 p. 1975 - 1978
反应条件
sodium amide; xylene
参考文献
Chemische Berichte, , vol. 57, p. 1804
Chemische Berichte, , vol. 58, p. 1733
反应条件
hydrogen bromide; bromine; sodium nitrite T=5°C;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: Et3N / CH2Cl2 2: 1.) n-BuLi / 1.) THF 3: 3N HCl / Heating 4: p-TsOH / pentan-1-ol / Heating View Scheme
参考文献
Cheng, Xinlai; Merz, Karl-Heinz; Vatter, Sandra; Christ, Jochen; Woelfl, Stefan; Eisenbrand, Gerhard
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 247 - 255
