4,6-二氯嘧啶-5-乙醛合成路线 (共 7 条)
反应条件
1: With K2OsO4*2H2O in water; acetone 0.0833333 h; 2: With sodium periodate in water; acetone T=20 - 40°C; 2 h;
参考文献
SCHERING CORPORATION; NEELAMKAVIL, Santhosh, Francis; BOYLE, Craig D.; NEUSTADT, Bernard, R.; CHACKALAMANNIL, Samuel; GREENLEE, William, J.
Patent: WO2010/9208 A1, 2010 ;
Location in patent: Page/Page column 73-74 ;
WO 2010/009208 A1
反应条件
1: phosphorus oxychloride 2: ozone / ethyl acetate View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 12 p. 1929 - 1937
反应条件
1: sodium methoxide 2: phosphorus oxychloride 3: ozone / ethyl acetate View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 12 p. 1929 - 1937
反应条件
1: 2-fluoro-4-(methanesulfonyl)benzenamine With sodium tris(acetoxy)borohydride; trifluoroacetic acid T=-15°C; 2: 2-(4,6-dichloropyrimidin-5-yl)acetaldehyde in dichloromethane T=-15 - 20°C;
参考文献
Boros, Eric E.; Thompson, James B.; Katamreddy, Subba R.; Carpenter, Andrew J.
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3587 - 3590
反应条件
ammonium chloride T=85°C; 5 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; AMIDON, Benjamin, S.; CARDIN, David, P.; GOULD, Alexandra, E.; GREENSPAN, Paul, D.; HARRISON, Sean, J.
Patent: WO2014/22744 A1, 2014 ;
Location in patent: Paragraph 0110 ;
反应条件
ammonium chloride in ethanol 20 h; Reflux;
参考文献
PFIZER LIMITED; ANDREWS, Mark, David; BAGAL, Sharanjeet, Kaur; BROWN, David, Graham; GIBSON, Karl, Richard; OMOTO, Kiyoyuki; RYCKMANS, Thomas; SABNIS, Yogesh; SKERRATT, Sarah, Elizabeth; STUPPLE, Paul, Anthony
Patent: WO2014/53967 A1, 2014 ;
Location in patent: Page/Page column 164; 165 ;
反应条件
sodium tetrahydroborate in methanol
T=0°C; 1 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2008/51404 A1, 2008 ;
Location in patent: Page/Page column 113 ;