3-(4-甲基苯基)-2-丙炔-1-醇合成路线 （共 12 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; PPh3 gold(I) chloro complex; triethylamine in N,N-dimethyl-formamide T=70°C; Sonogashira type cross-coupling; 0.75 h; Inert atmosphere;
参考文献
Panda, Biswajit; Sarkar, Tarunk.
Synthesis (Germany), 2013 , vol. 45, # 6 art. no. SS-2012-Z0931-OP, p. 817 - 829
反应条件
diisopropylammonium bromide; [(t-Bu)3PH]BF4; copper(l) iodide; Na2[PdCl4] in various solvent(s) T=80°C; Sonogashira coupling; 14 h;
参考文献
Koellhofer, Axel; Plenio, Herbert
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 9 p. 1295 - 1300
反应条件
1: 4-methyl phenyl acetylene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.666667 h; Inert atmosphere; 2: formaldehyd in tetrahydrofuran; hexane T=-78 - 20°C; 16 h; Inert atmosphere;
参考文献
Everett, Renata K.; Wolfe, John P.
Organic Letters, 2013 , vol. 15, # 12 p. 2926 - 2929
反应条件
2,6-di-tert-butyl-4-methylpyridine; gold(I) chloride; palladium dichloride; SIDip*HCl in acetonitrile T=20°C; Sonogashira coupling;
参考文献
Panda, Biswajit; Sarkar, Tarun K.
Chemical Communications, 2010 , vol. 46, # 18 p. 3131 - 3133
反应条件
ethanol; pyridinium p-toluenesulfonate T=20°C;
参考文献
Maji, Manasi; Mallick, Dibyendu; Mondal, Sayantan; Anoop, Anakuthil; Bag, Subhendu Sekhar; Basak, Amit; Jemmis, Eluvathingal D.
Organic Letters, 2011 , vol. 13, # 5 p. 888 - 891
反应条件
sodium hydroxide; water in acetone Combinatorial reaction / High throughput screening (HTS);
参考文献
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE RENNES 1
Patent: US2007/43234 A1, 2007 ;
Location in patent: Page/Page column 58 ;
反应条件
1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / 2 h / 20 °C / Inert atmosphere 2: ethanol; pyridinium p-toluenesulfonate / 20 °C View Scheme
参考文献
Maji, Manasi; Mallick, Dibyendu; Mondal, Sayantan; Anoop, Anakuthil; Bag, Subhendu Sekhar; Basak, Amit; Jemmis, Eluvathingal D.
Organic Letters, 2011 , vol. 13, # 5 p. 888 - 891
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine
参考文献
Isaac, Methvin; Slassi, Abdelmalik; Silva, Kathleen Da; Arora, Jalaj; MacLean, Neil; Hung, Bill; McCallum, Kirk
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 11 p. 1371 - 1373
反应条件
manganese(IV) oxide; potassium hydroxide in diethyl ether
参考文献
Journal of Organic Chemistry, , vol. 62, # 21 p. 7471 - 7474
反应条件
hydrogen; triphenylphosphine; dirhodium tetraacetate in dichloromethane
T=65°C; P=36200.4 Torr; 24 h;
参考文献
Nanayakkara, Peru; Alper, Howard
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 4-5 p. 545 - 550
