2,6-二氯-3-硝基吡啶合成路线 （共 74 条）
反应条件
N,N,N',N'-tetra-methylnaphthalene-1,8-diamine; triethylamine tris(hydrogen fluoride) in acetonitrile T=80°C; 72 h;
参考文献
Darabantu, Mircea; Lequeux, Thierry; Pommelet, Jean-Claude; Ple, Nelly; Turck, Alain
Tetrahedron, 2001 , vol. 57, # 4 p. 739 - 750
反应条件
1: ammonium hydroxide / 5 h / 50 °C 2: ethanol / 16 h / -15 - 20 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1: SnCl2 / pH <7 2: HBF4 / Heating View Scheme
参考文献
Remuzon, Philippe; Bouzard, Daniel; Jacquet, Jean-Pierre
Heterocycles, 1993 , vol. 36, # 3 p. 431 - 434
反应条件
iron; acetic acid T=20°C; 6 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; THIBEAULT, Carl; CLARK, Charles, G.; DELUCCA, Indawati; HU, Carol, Hui; JEON, Yoon; LAM, Patrick, Y., S.; QIAO, Jennifer, X.; YANG, Wu; WANG, Yufeng; WANG, Tammy, C.
Patent: WO2014/22349 A1, 2014 ;
Location in patent: Paragraph 00221-00222 ;
反应条件
iron; toluene-4-sulfonic acid in acetic acid; toluene
参考文献
SmithKline Beecham p.l.c.; Symphar SA
Patent: US6303784 B1, 2001 ;
反应条件
in tetrahydrofuran T=-78 - -20°C; 1 h;
参考文献
SYNGENTA PARTICIPATIONS AG; EDMUNDS, Andrew; BIGOT, Aurelien; HALL, Roger Graham; JEANGUENAT, André; LUKSCH, Torsten; RENDLER, Sebastian
Patent: WO2013/156431 A1, 2013 ;
Location in patent: Page/Page column 47 ;
反应条件
hydrogenchloride; hydrogen; sodium hydride; nickel Yield given. Multistep reaction;
参考文献
Robinson, Ralph P.; Donahue, Kathleen M.; Son, Paul S.; Wagy, Steven D.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 2 p. 287 - 293
反应条件
1.1: sodium hydride / ethylene glycol dimethyl ether / 2 h / 20 °C 1.2: 18 h / 20 °C 2.1: hydrogen / ethanol; water / 48 h / 2280.15 Torr 2.2: 5 h / |Reflux View Scheme
参考文献
Hoffmann-La Roche Inc.; Alam, Muzaffar; Du Bois, Daisy Jo; Hawley, Ronald Charles; Minatti, Ana Elena; Kennedy-Smith, Joshua; Thakkar, Kshitij Chhabilbhai; Wilhelm, Robert Stephen
Patent: US2013/158066 A1, 2013 ;
反应条件
in water; ethyl acetate; toluene
参考文献
Simoneau, Bruno
Patent: US2002/28807 A1, 2002 ;
反应条件
triethylamine in tert-butyl methyl ether T=-5 - 20°C; Inert atmosphere;
参考文献
Deasy, Rebecca E.; Slattery, Catherine N.; Maguire, Anita R.; Kjell, Douglas P.; Hawk, Mai Khanh N.; Joo, Jung Min; Gu, Rui Lin; Moynihan, Humphrey
Journal of Organic Chemistry, 2014 , vol. 79, # 8 p. 3688 - 3695
