N-(苄氧羰基)-L-丙氨酰-L-丙氨酸合成路线 （共 33 条）
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine in dichloromethane 1.) 4 deg C, 2 h, 2.) room temperature, 2 d;
参考文献
Johnson, Arthur F.; Struthers, Mary D.; Pierson, Keith B.; Mangel, Walter F.; Smith, Lloyd M.
Analytical Chemistry, 1993 , vol. 65, # 17 p. 2352 - 2359
反应条件
1: 78 percent / pyridine, DMF, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / 1.) 4 deg C, 2 h, 2.) room temperature, 2 d 2: 84 percent / aq. HBr, acetic acid / 0.67 h / Ambient temperature 3: 33 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, triethylamine / CH2Cl2 / 1.) 4 deg C, 2 h, 2.) room temperature, 2 d View Scheme
参考文献
Johnson, Arthur F.; Struthers, Mary D.; Pierson, Keith B.; Mangel, Walter F.; Smith, Lloyd M.
Analytical Chemistry, 1993 , vol. 65, # 17 p. 2352 - 2359
反应条件
1-hydroxy-pyrrolidine-2,5-dione; potassium carbonate; dicyclohexyl-carbodiimide 1.) THF, 4 h; 2.) 20 h; Yield given. Multistep reaction;
参考文献
Albeck, Amnon; Persky, Rachel
Tetrahedron, 1994 , vol. 50, # 21 p. 6333 - 6346
反应条件
1: 87 percent / NEt3, ethyl chlorocarbonate / tetrahydrofuran; dimethylformamide / 1.) -10 deg C, pH 7.5, 1 h; 2.) 4 deg C, overnight 2: 100 percent / 2 N HCl, H2 / Pd / methanol 3: 83 percent / pyridine / 3 h / Ambient temperature View Scheme
参考文献
Jahreis, Guenther; Fittkau, Siegfried
Journal fuer Praktische Chemie (Leipzig), 1984 , vol. 326, # 1 p. 35 - 40
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.33 h / -15 °C 2: N-methylmorpholine / CH2Cl2 / 1 h / -15 °C 3: H2 / Pd/C / methanol / 24 h / 4654.33 Torr View Scheme
参考文献
Zou, Weibiao; Ibrahem, Ismail; Dziedzic, Pawel; Sunden, Henrik; Cordova, Armando
Chemical Communications, 2005 , # 39 p. 4946 - 4948
反应条件
ethylenediaminetetraacetic acid; water; papain in dichloromethane T=40°C; 24 h;
参考文献
Pharmazie, , vol. 52, # 3 p. 203 - 206
反应条件
1: HBr-AcOH, anisole / 1 h / Ambient temperature 2: 87 percent / aq. Et3N / tetrahydrofuran / 72 h / Ambient temperature View Scheme
参考文献
Nagao, Yoshimitsu; Miyasaka, Tadayo; Seno, Kaoru; Fujita, Eiichi; Shibata, Daisuke; Doi, Etsushiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2439 - 2446
反应条件
hydrogen; K3[Co(CN)5] in methanol T=20°C; 3 h;
参考文献
Losse, Guenter; Stiehl, Hans-Ulrich
Zeitschrift fuer Chemie (Stuttgart, Germany), 1981 , vol. 21, # 5 p. 188
反应条件
sodium hydroxide in methanol
below 5 deg C;
参考文献
Iida; Yoshimatsu; Sanekata; Fujita
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 11 p. 2997 - 3003
反应条件
n-ethyl morpholine in tetrahydrofuran; N-methyl-acetamide; water
参考文献
Hoffmann-La Roche Inc.
Patent: US4176116 A1, 1979 ;
