5-氟-2-甲基-4,6-二羟基嘧啶合成路线 （共 4 条）
反应条件
1: With sodium methylate in methanol T=20°C; 2: With hydrogenchloride in water pH=3 - 5;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/61879 A1, 2009 ;
Location in patent: Page/Page column 60-61 ;
反应条件
1: With ethanol; sodium T=20°C; 3 h; Heating / reflux; 2: With hydrogenchloride; water T=20°C; pH=2; 1 h;
参考文献
ICAGEN, INC.
Patent: US2007/197523 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
in diethyl ether; water; 1-Imino-ethanamine hydrochloride; ethyl acetate
参考文献
American Home Products Corporation
Patent: US4617393 A1, 1986 ;
反应条件
trichlorophosphate T=120°C; 3 h;
参考文献
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED; AUBART, Kelly, Marshall; GILLIAN, Jason, Michael; QIN, Donghui; MCKEOWN, Robert, Rahn; WILLIAMS, Glenn, R.
Patent: WO2013/82388 A1, 2013 ;
Location in patent: Page/Page column 67 ;
