L-proline in methanol T=25°C; organocatalytic Knoevenagel condensation; 12 h;

1: sodium 2-(ethoxycarbonyl)-1-oxo-1H-inden-3-olate With sulfuric acid; acetic acid T=50°C; 0.0833333 h; 2: 4-nitrobenzaldehdye T=50°C; 1 h;

1: sodium 2-(ethoxycarbonyl)-1-oxo-1H-inden-3-olate With sulfuric acid; acetic acid T=50°C; 0.0833333 h; 2: 4-chlorobenzaldehyde T=50°C; 1 h;

in ethanol Ambient temperature;

1: sodium / ethanol 2: 86.02 percent / piperidine / ethanol / 3 h / Heating View Scheme

1: 2-(4-nitro-benzyl)-indan-1,3-dione With potassium hydride in acetonitrile T=20°C; 0.333333 h; Inert atmosphereGlovebox; 2: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium in acetonitrile T=24.84°C; Inert atmosphereGlovebox; Thermodynamic data;

in acetic acid 0.416667 h; Heating;