2-甲氧基-5-氰基吡啶合成路线 （共 15 条）
反应条件
1,8-bis(diisopropylphosphino)triptycene; potassium phosphate; palladium diacetate in N,N-dimethyl-formamide T=90°C;
参考文献
Grossman, Olga; Gelman, Dmitri
Organic Letters, 2006 , vol. 8, # 6 p. 1189 - 1191
反应条件
racemic 2-di-tert-butylphosphino-1,1'-binaphthyl; palladium (II) trifluoroacetate; zinc in N,N-dimethyl acetamide T=80°C; 3 h;
参考文献
Littke, Adam; Soumeillant, Maxime; Kaltenbach III, Robert F.; Cherney, Robert J.; Tarby, Christine M.; Kiau, Susanne
Organic Letters, 2007 , vol. 9, # 9 p. 1711 - 1714
反应条件
copper(I) thiophene-2-carboxylate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=100°C; 12 h;
参考文献
Zhang, Zhihui; Liebeskind, Lanny S.
Organic Letters, 2006 , vol. 8, # 19 p. 4331 - 4333
反应条件
in N,N-dimethyl-formamide T=120 - 140°C; 41 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1621537 A1, 2006 ;
Location in patent: Page/Page column 27 ;
反应条件
in methanol 20 h; Heating / reflux;
参考文献
N.V. Organon; Pharmacopeia Drug Discovery Inc.
Patent: US2007/149577 A1, 2007 ;
Location in patent: Page/Page column 17-18 ;
反应条件
L-proline in N,N-dimethyl-formamide T=120°C; Rosenmund-von Braun reaction; 45 h;
参考文献
Wang, Deping; Kuang, Liping; Li, Zhengwei; Ding, Ke
Synlett, 2008 , # 1 p. 69 - 72
反应条件
1: POCl3 / Behandeln des Reaktionsprodukts in Aceton mit wss. NH3 2: POCl3; CHCl3 3: methanol; dioxane View Scheme
参考文献
Journal of the Chemical Society, , p. 1939,1942
反应条件
1: POCl3; CHCl3 2: methanol; dioxane View Scheme
参考文献
Journal of the Chemical Society, , p. 1939,1942
反应条件
formaldehyd; sodium acetate; nickel monoaluminide in hydrogenchloride; ethanol; water
参考文献
Smith Kline and French Laboratories Limited
Patent: US4234588 A1, 1980 ;
反应条件
hydrogenchloride; formaldehyd; hydrogen; semicarbazide-hydrochloride; sodium acetate; nickel 1.) EtOH, H2O, 50 psi, 2.) EtOH, H2O, heating, 15 min; Yield given. Multistep reaction;
参考文献
Brown, T. H.; Blakemore, R. C.; Durant, G. J.; Ganellin, C. R.; Parsons, M. E.; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 601 - 608
