(R)-1-苯基-2-丙醇合成路线 （共 57 条）
反应条件
sodium hydroxide T=25°C; 4 h;
参考文献
Journal of Organic Chemistry, , vol. 53, # 23 p. 5531 - 5534
反应条件
isopropyl alcohol; 1-n-butyl-3-methylimidazolium bistrifluoromethylsulfonylamide T=40°C; pH=6; Microbiological reaction;
参考文献
Schroer, Kirsten; Tacha, Eva; Luetz, Stephan
Organic Process Research and Development, 2007 , vol. 11, # 5 p. 836 - 841
反应条件
1: 85 percent / 4-(dimethylamino)pyridine; pyridine / 3 h / 30 °C 2: triethylamine / 3 h / 75 - 80 °C 3: aq. LiOH / methanol / 3 h / 20 °C View Scheme
参考文献
Journal of Chemical Research, , # 10 p. 681 - 683
反应条件
lipase from candida antartica in aq. phosphate buffer T=30°C; 48 h;
参考文献
Kataoka, Noriyuki; Okudomi, Masayuki; Chihara, Naoka; Matsumoto, Kazutsugu
Letters in Organic Chemistry, 2012 , vol. 9, # 9 p. 615 - 621
反应条件
1: With (S)-2-methyl-quinazolinap rhodium; benzo[1,3,2]dioxaborole in tetrahydrofuran T=0°C; 2 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; ethanol T=0 - 20°C; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6572 - 6589
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; Inert atmosphere; 2: With immobilized Candida antarctica Lipase B; water in hexane T=30°C; pH=6.5; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 66, # 40 p. 8060 - 8067
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; Inert atmosphere; 2: With immobilized Candida antarctica Lipase B; water in hexane T=30°C; pH=6.5; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 66, # 40 p. 8060 - 8067
反应条件
sodium hydroxide T=25°C; 4 h;
参考文献
Journal of Organic Chemistry, , vol. 53, # 23 p. 5531 - 5534
反应条件
1: With (R)-2-tert-butyl-quinazolinap rhodium; benzo[1,3,2]dioxaborole in tetrahydrofuran T=20°C; 2 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; ethanol T=0 - 20°C; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6572 - 6589
反应条件
1: With vinyl acetate; immobilized Novozym 435(R) Candida antarctica lipase-B in hexane T=32°C; 72 h; 2: With triphenylstannane; 1,1'-azobis (cyclohexanecarbonitrile) in hexane; toluene 4 h; Heating; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 24 p. 3945 - 3954
