(R)-1-苯基-2-丙醇合成路线 (共 57 条)
反应条件
air; cells of Geotrichum candidum IFO 5767 in water T=30°C; 24 h;
参考文献
Nakamura, Kaoru; Fujii, Mikio; Ida, Yoshiteru
Tetrahedron Asymmetry, 2001 , vol. 12, # 22 p. 3147 - 3153
反应条件
hydrogen; Pd/magnetite in ethyl acetate T=23°C; P=760.051 Torr; 0.7 h;
参考文献
Organic Letters, , vol. 9, # 17 p. 3417 - 3419
反应条件
methanesulfonic acid; (R,R)-dihydroborate in hexane T=-20°C; 48 h; Title compound not separated from byproducts;
参考文献
Imai, Toshiro; Tamura, Tadashi; Yamamuro, Akira; Sato, Tsuneo; Wollmann, Theodor A.; et al.
Journal of the American Chemical Society, 1986 , vol. 108, # 23 p. 7402 - 7404
反应条件
1: bromobenzene With magnesium in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: With copper (I) cyanide in tetrahydrofuran T=-35°C; 0.5 h; 3: (R)-(+)-propylene oxide in tetrahydrofuran T=-35 - 20°C; 1.5 h;
参考文献
Taguri, Tomonori; Yamamoto, Masanobu; Fujii, Toru; Muraki, Yuta; Ando, Tetsu
European Journal of Organic Chemistry, 2013 , # 30 p. 6924 - 6933
反应条件
1: With titanium(IV) isopropylate; (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol in diethyl ether; toluene T=0°C; 1 h; Inert atmosphere; 2: With hydrogenchloride in diethyl ether; water; toluene Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 23, # 10 p. 789 - 794
反应条件
ethanol; nickel T=50°C; or nBu3SnH, AIBN, toluene, reflux;
参考文献
DeNinno; Perner; Lijewski
Tetrahedron Letters, 1990 , vol. 31, # 51 p. 7415 - 7418
反应条件
(1R)-N-oxyl-1-(N-benzylcarbamoyl)-8-azabicyclo[3.2.1]octane; sodium hydrogencarbonate; sodium bromide in dichloromethane; water T=0°C; Electrochemical reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Demizu, Yosuke; Shiigi, Hirofumi; Mori, Hiroyuki; Matsumoto, Kazuya; Onomura, Osamu
Tetrahedron Asymmetry, 2008 , vol. 19, # 23 p. 2659 - 2665
反应条件
Candida antarctica lipase B; (η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate; sodium carbonate in tetrahydrofuran; toluene T=20°C; 6 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 127, # 24 p. 8817 - 8825
反应条件
[bis(acetoxy)iodo]benzene; potassium bromide in dichloromethane; water T=20°C; 1 h;
参考文献
Helvetica Chimica Acta, , vol. 90, # 3 p. 623 - 626
反应条件
polyoxyethylene (10) cetyl ether; n-octyl beta-D-glucopyranoside; subtilisin Carlsberg; sodium carbonate in tetrahydrofuran T=20°C; 17 h; Title compound not separated from byproducts;
参考文献
Chemistry - A European Journal, , vol. 12, # 1 p. 225 - 232