4-溴-1-(溴甲基)-2-甲基苯合成路线 （共 6 条）
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=0 - 5°C;
参考文献
SMITHKLINE BEECHAM CORPORATION; BOUILLOT, Anne Marie Jeanne; DODIC, Nerina; GELLIBERT, Francoise Jeanne; MIRGUET, Olivier
Patent: WO2010/15652 A2, 2010 ;
Location in patent: Page/Page column 36 ;
WO 2010/015652 A2
反应条件
1.1: thionyl chloride / 1 h / |Reflux 1.2: 0 °C 2.1: lithium aluminium tetrahydride / dichloromethane / 16 h / 0 - 20 °C 3.1: phosphorus tribromide / dichloromethane / 3 h / 0 - 20 °C View Scheme
参考文献
Smith, Jake A.; Moeller, Kevin D.
Organic Letters, 2013 , vol. 15, # 22 p. 5818 - 5821
反应条件
1: lithium aluminium tetrahydride / dichloromethane / 16 h / 0 - 20 °C 2: phosphorus tribromide / dichloromethane / 3 h / 0 - 20 °C View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
反应条件
in water; N,N-dimethyl-formamide T=0 - 20°C;
参考文献
ASTRAZENECA AB
Patent: WO2008/18827 A1, 2008 ;
Location in patent: Page/Page column 61-62 ;
WO 2008/018827 A1
反应条件
tetrabutylammomium bromide in dichloromethane; water T=0 - 20°C; 16 h;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00620 ;
WO 2013/043232 A2
反应条件
in water; N,N-dimethyl-formamide T=80°C; 72 h;
参考文献
SANKYO COMPANY, LIMITED
Patent: WO2006/109633 A1, 2006 ;
Location in patent: Page/Page column 168-169 ;
