比马前列素合成路线

参考文献

Biffi, Giancarlo; D'Alfonso, Alessandro; Feliciani, Lazzaro; Porta, Alessio; Vidari, Giovanni; Viscardi, Enrico; Zanoni, Giuseppe
Patent: US2012/16136 A1, 2012 ;
Location in patent: Page/Page column 8-9 ;

1163135-95-25-反式-比马前列素+

155206-00-1比马前列素

参考文献

INSTYTUT FARMACEUTYCZNY; DAMS, Iwona; KUTNER, Andrzej; CHODYŃSKI, Michał; KRUPA, Małgorzata; PIETRASZEK, Anita; ZEZULA, Marta; CMOCH, Piotr; KOSIŃSKA, Monika
Patent: WO2013/133730 A1, 2013 ;
Location in patent: Page/Page column 61; 62 ;

107-10-8正丙胺+

130209-76-6比马前列素异丙酯

155206-00-1比马前列素

参考文献

ScinoPharm Taiwan Ltd.
Patent: US2009/259058 A1, 2009 ;
Location in patent: Page/Page column 22-23 ;

856240-62-5拉坦前列素中间体+

1201226-16-5

155206-00-1比马前列素

参考文献

EP2135860 A1, ;

Page/Page column 17 ;

75-04-7乙胺+

38344-08-0(Z)-7-[(1R,2R,3S,5S)-3,5-二羟基-2-[(E)-3-羟基-5-苯基戊-1-烯基]环戊基]庚-5-烯酸

155206-00-1比马前列素

参考文献

WO2012/164324 A1, ;

Page/Page column 33-34 ;

1300092-94-7

155206-00-1比马前列素

参考文献

WO2011/55377 A1, ;

Page/Page column 26; 37 ;

75-04-7乙胺+

38315-47-8(Z)-7-[(1r,2r,3r,5s)-3,5-二羟基-2-((e)-(s)-3-羟基-5-苯基-1-戊烯)-环戊基]-5-庚烯酸甲酯

155206-00-1比马前列素

参考文献

Gutman, Arie; Rukhman, Igor; Tishin, Boris; Yudovich, Lev; Vilensky, Alexander; Pertsikov, Boris; Nisnevich, Gennady
Patent: US2009/163596 A1, 2009 ;
Location in patent: Page/Page column 18 ;

856240-62-5拉坦前列素中间体+

17814-85-64-羧丁基三苯基溴化膦+

75-04-7乙胺

155206-00-1比马前列素

参考文献

WO2012/11128 A1, ;

Page/Page column 21-22 ;

155206-00-1比马前列素

参考文献

IRIX PHARMACEUTICALS; YIANNIKOUROS, George, Petros; KALARITIS, Panos; GAMAGE, Chaminda, Priyapushpa; ABERNATHY, Stephanie, Bosse
Patent: WO2011/8756 A1, 2011 ;
Location in patent: Page/Page column 62 ;

960056-50-2+

75-04-7乙胺

155206-00-1比马前列素

参考文献

Zanoni, Giuseppe; D'Alfonso, Alessandro; Porta, Alessio; Feliciani, Lazzaro; Nolan, Steven P.; Vidari, Giovanni
Tetrahedron, 2010 , vol. 66, # 38 p. 7472 - 7478