1.1: dimethyl zinc / naphthalene-1-sulfonic acid ((R)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl)-amide / n-heptane; toluene / 1.5 h / 20 °C / Inert atmosphere 1.2: 20 h / 20 °C 2.1: ethyl acetate / 1.5 h / 0 - 20 °C 2.2: 18 h / 0 - 20 °C 3.1: potassium phosphate; trans-N,N'-dimethylcyclohexane-1,2-diamine / copper(l) iodide / toluene / 24 h / 120 °C / Inert atmosphere View Scheme

1.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere 2.1: (9R)-1-[3,5-bis(trifluoromethyl)benzyl]cinchonan-1-ium-9-ol bromide; tetramethyl-ammonium fluoride / dichloromethane; toluene / 2 h / -40 °C / Inert atmosphere 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 4.1: iron; acetic acid / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere 5.1: potassium hydrogencarbonate / tert-butyl methyl ether; water / 1 h / 20 °C / Inert atmosphere 5.2: pH 12 / Inert atmosphere View Scheme

1.1: (9R)-1-[3,5-bis(trifluoromethyl)benzyl]cinchonan-1-ium-9-ol bromide; tetramethyl-ammonium fluoride / dichloromethane; toluene / 2 h / -40 °C / Inert atmosphere 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 3.1: iron; acetic acid / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere 4.1: potassium hydrogencarbonate / tert-butyl methyl ether; water / 1 h / 20 °C / Inert atmosphere 4.2: pH 12 / Inert atmosphere View Scheme

1.1: triethylamine; zinc(II) chloride / toluene / 17 h / 20 °C / Inert atmosphere 2.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere 3.1: (9R)-1-[3,5-bis(trifluoromethyl)benzyl]cinchonan-1-ium-9-ol bromide; tetramethyl-ammonium fluoride / dichloromethane; toluene / 2 h / -40 °C / Inert atmosphere 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 5.1: iron; acetic acid / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere 6.1: potassium hydrogencarbonate / tert-butyl methyl ether; water / 1 h / 20 °C / Inert atmosphere 6.2: pH 12 / Inert atmosphere View Scheme

[(N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)-1,2-diaminoethane)Fe(triflate)2]; dihydrogen peroxide; acetic acid in ethyl acetate; acetonitrile T=40°C; 72 h;

[(N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)-1,2-diaminoethane)Fe(triflate)2]; dihydrogen peroxide; acetic acid in ethyl acetate; acetonitrile T=40°C; 72 h;

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