依法韦仑合成路线

1381993-90-3

参考文献

LONZA LTD; LONZA GUANGZHOU RESEARCH AND DEVELOPMENT CENTER LTD; DAI, Danmei; LONG, Xiangtian; LUO, Bing; KULESZA, Anna; REICHWAGEN, Jens; GUO, Yanming
Patent: WO2012/97511 A1, 2012 ;
Location in patent: Page/Page column 60-61 ;

32315-10-9三光气+

209414-27-7(S)-1-(2-氨基-5-氯苯基)-1-三氟甲基-3-环丙基-2-丙炔-1-醇+

503-38-8氯甲酸三氯甲酯

154598-52-4依法韦仑

参考文献

LONZA LTD; BRENNER, Meinrad; CARREIRA, Erick, M.; CHINKOV, Nicka; LORENZI, Miriam; WARM, Aleksander; ZIMMERMANN, Lothar
Patent: WO2012/48886 A1, 2012 ;
Location in patent: Page/Page column 34 ;

1381993-90-3

154801-74-8(R)-依法韦仑+

154598-52-4依法韦仑

参考文献

LONZA LTD; LONZA GUANGZHOU RESEARCH AND DEVELOPMENT CENTER LTD; DAI, Danmei; LONG, Xiangtian; LUO, Bing; KULESZA, Anna; REICHWAGEN, Jens; GUO, Yanming
Patent: WO2012/97510 A1, 2012 ;
Location in patent: Page/Page column 60-61 ;

102-09-0碳酸二苯酯

154598-52-4依法韦仑

参考文献

LUPIN LIMITED; SINGH, Girij, Pal; SINGH, Gurvinder, Pal; MAHAJAN, Pravin; SALUNKE, Ganesh; KARNALKAR, Dabeer
Patent: WO2011/7367 A1, 2011 ;
Location in patent: Page/Page column 5-6 ;

102-09-0碳酸二苯酯+

209414-27-7(S)-1-(2-氨基-5-氯苯基)-1-三氟甲基-3-环丙基-2-丙炔-1-醇

154598-52-4依法韦仑

参考文献

LUPIN LIMITED
Patent: US2012/108809 A1, 2012 ;
Location in patent: Page/Page column 2-3 ;

32315-10-9三光气+

209414-27-7(S)-1-(2-氨基-5-氯苯基)-1-三氟甲基-3-环丙基-2-丙炔-1-醇

154598-52-4依法韦仑

参考文献

EMCURE PHARMACEUTICALS LIMITED; GURJAR, Mukund, Keshav; DESHMUKH, Abdulrakheeb, Abdulsubhan; DESHMUKH, Sanjay, Shankar; MEHTA, Satish, Ramanlal
Patent: WO2010/32259 A2, 2010 ;
Location in patent: Page/Page column 16; 17 ;

530-62-1N,N'-羰基二咪唑+

209414-27-7(S)-1-(2-氨基-5-氯苯基)-1-三氟甲基-3-环丙基-2-丙炔-1-醇

154598-52-4依法韦仑

参考文献

LUPIN LIMITED
Patent: US2012/108809 A1, 2012 ;
Location in patent: Page/Page column 2 ;

530-62-1N,N'-羰基二咪唑

154598-52-4依法韦仑

参考文献

LUPIN LIMITED; SINGH, Girij, Pal; SINGH, Gurvinder, Pal; MAHAJAN, Pravin; SALUNKE, Ganesh; KARNALKAR, Dabeer
Patent: WO2011/7367 A1, 2011 ;
Location in patent: Page/Page column 5 ;

211563-40-5(4S)-6-氯-4-(环丙基乙炔基)-2-氧代-4-(三氟甲基)-2H-3,1-苯并恶嗪-1(4H)-羧酸甲酯

154598-52-4依法韦仑

参考文献

MERCK and CO., INC.
Patent: EP968197 B1, 2005 ;
Location in patent: Page/Page column 16 ;

75-44-5光气

154598-52-4依法韦仑

参考文献

LONZA LTD; GRIFFITHS, Gareth-John; LORENZI, Miriam; WARM, Aleksander
Patent: WO2010/115641 A1, 2010 ;
Location in patent: Page/Page column 9 ;