Cbz-s-苯基-d-cys合成路线 （共 13 条）
反应条件
potassium carbonate; tetra-(n-butyl)-phosphonium bromide in toluene
T=25°C; 24 - 192 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: EP1236715 A2, 2002 ;
Location in patent: Example 9; 10 ;
反应条件
hydrogenchloride in N-methyl-acetamide; hexane; water; toluene
参考文献
F. Hoffmann-La Roche AG
Patent: US6229041 B1, 2001 ;
反应条件
copper in N,N-dimethyl-formamide
T=70 - 130°C; 44.5 - 53.5 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: EP1236715 A2, 2002 ;
Location in patent: Example 3; 4 ;
参考文献
F. Hoffmann-La Roche AG
Patent: US6229041 B1, 2001 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
1.) 10 min, 2.) 20 deg C, 16 h;
参考文献
Knight, David W.; Sibley, A. William
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 15 p. 2179 - 2187
反应条件
in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Knight; Sibley
Tetrahedron Letters, 1993 , vol. 34, # 41 p. 6607 - 6610
反应条件
bromine in N-methyl-acetamide
参考文献
F. Hoffmann-La Roche AG
Patent: US6229041 B1, 2001 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in water; toluene
T=25°C; 23.5 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: EP1236715 A2, 2002 ;
Location in patent: Page 13 ;
反应条件
copper; copper(ll) bromide in dimethyl sulfoxide
T=120 - 130°C; 1.25 - 19.25 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: EP1236715 A2, 2002 ;
Location in patent: Example 18 ;
反应条件
copper; copper(ll) bromide in dimethyl sulfoxide
T=100°C; 18 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: EP1236715 A2, 2002 ;
Location in patent: Example 19 ;
