(R)-(+)-1-苯基乙醇合成路线 （共 353 条）
反应条件
mono-[6-2(S)-hydroxypropylamino-6-deoxy]-β-cyclodextrin; sodium lt;1-(2)Hgt;formate; [Ru(II)(η6-benzene)(μ-Cl)Cl]2 in water; N,N-dimethyl-formamide T=20°C; 24 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 43, # 48 p. 6731 - 6734
反应条件
in tetrahydrofuran T=5°C; 1 h; Product distribution / selectivity;
参考文献
UNIVERSITY OF NOTTINGHAM
Patent: WO2006/79819 A2, 2006 ;
Location in patent: Page/Page column 32-33; 37 ;
反应条件
triethylamine in tert-butyl methyl ether T=50°C; 216 h; Inert atmosphereEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Quijada, F. Javier; Gotor, Vicente; Rebolledo, Francisca
Organic Letters, 2010 , vol. 12, # 16 p. 3602 - 3605
反应条件
triethylamine in tert-butyl methyl ether T=50°C; 216 h; Inert atmosphereEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Quijada, F. Javier; Gotor, Vicente; Rebolledo, Francisca
Organic Letters, 2010 , vol. 12, # 16 p. 3602 - 3605
反应条件
phosphite dehydrogenase; recombinant phenylacetone monooxygenase from Thermobifida fusca; NADPH in dimethyl sulfoxide T=30°C; pH=9; 3 h; Tris/HCl bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 353, # 11-12 p. 2169 - 2173
反应条件
{RuCl(μ-Cl)(η6-p-mesitylene)}2; C45H77NO35; sodium formate in water; N,N-dimethyl-formamide T=25°C; 96 h; Overall yield = 67.33 percentChromat.; enantioselective reaction;
参考文献
Tetrahedron, , vol. 69, # 39 p. 8360 - 8367
反应条件
hydrogen; lipase B from Candida antarctica in toluene T=70°C; P=750.075 Torr; 48 h; Resolution of racemateEnzymatic reaction;
参考文献
European Journal of Organic Chemistry, , vol. 2014, # 14 p. 2917 - 2923
反应条件
hydrogen; lipase B from Candida antarctica in toluene T=70°C; P=750.075 Torr; 48 h; Resolution of racemateEnzymatic reaction;
参考文献
European Journal of Organic Chemistry, , vol. 2014, # 14 p. 2917 - 2923
反应条件
alcohol dehydrogenase from Thermoanaerobium brockii; NADH-specific (R)-selective-ADH; YcnD-oxidoreductase T=30°C; pH=7.5; 6 h; aq. bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantiospecific reaction;
参考文献
Voss, Constance V.; Gruber, Christian C.; Faber, Kurt; Knaus, Tanja; Macheroux, Peter; Kroutil, Wolfgang
Journal of the American Chemical Society, 2008 , vol. 130, # 42 p. 13969 - 13972
反应条件
rabbit liver microsomal cytochrome P-450 in water T=25°C; 12 h;
参考文献
Journal of the American Chemical Society, , vol. 108, # 19 p. 6024 - 6031
