2-氨基异丁酸甲酯盐酸盐合成路线 （共 17 条）
反应条件
T=0°C; nachfolgendem Aufbewahren;
参考文献
Barker; Skinner
Journal of the American Chemical Society, 1924 , vol. 46, p. 412
反应条件
sodium tetrahydroborate; sodium hydrogencarbonate
参考文献
Bayer Corporation
Patent: US6353006 B1, 2002 ;
Location in patent: Page column 138 ;
US 6353006 B1
参考文献
Leibfritz, Dieter; Haupt, Erhard; Dubischar, Norbert; Lachmann, Heinrich; Oekonomopulos, Raymond; Jung, Guenther
Tetrahedron, 1982 , vol. 38, # 14 p. 2165 - 2182
反应条件
1: 4-trifluoromethoxy-aniline; trichloromethyl chloroformate in toluene
T=-20 - 20°C; 3.25 h; Heating / reflux;
2: methyl 2-amino-2-methylpropionate hydrochloride With triethylamine in toluene
T=20°C; 16 h; Heating / reflux;
参考文献
AVENTIS PHARMA S.A.
Patent: US2004/248884 A1, 2004 ;
Location in patent: Page 51 ;
US 20040248884 A1
反应条件
triethylamine in toluene
T=20°C; 24 h; Heating / reflux;
参考文献
AVENTIS PHARMA S.A.
Patent: US2004/248884 A1, 2004 ;
Location in patent: Page 108-109 ;
US 20040248884 A1
反应条件
1: 1-hydroxy-naphthalene-2-carboxylic acid With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide
T=0°C; 0.5 h;
2: methyl 2-amino-2-methylpropionate hydrochloride With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
SANOFI-AVENTIS
Patent: WO2008/409 A1, 2008 ;
Location in patent: Page/Page column 103-104 ;
WO 2008/000409 A1
反应条件
thionyl chloride in methanol
参考文献
Universitetet i Oslo
Patent: US2011/263479 A1, 2011 ;
