4-溴-2-(溴甲基)-1-氯苯合成路线 （共 4 条）
反应条件
2,6-dimethylpyridine; carbon tetrabromide; triphenylphosphine in N,N-dimethyl acetamide T=20°C; 20 h;
参考文献
Leclerc, Jean-Philippe; Andre, Mathieu; Fagnou, Keith
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1711 - 1714
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 2 h; Heating / reflux;
参考文献
Gruenenthal GmbH
Patent: US2009/69320 A1, 2009 ;
Location in patent: Page/Page column 77; 78 ;
反应条件
sodium hydrogencarbonate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; tert-butyl methyl ether; water
参考文献
Sumitomo Chemical Company, Limited
Patent: US6489487 B1, 2002 ;
反应条件
1: 98 percent / BH3; Me2S / tetrahydrofuran / 24 h / 20 °C 2: 100 percent / CBr4; PPh3; 2,6-lutidine / N,N-dimethyl-acetamide / 20 h / 20 °C View Scheme
参考文献
Thorarensen, Atli; Presley-Bodnar, Alice L.; Marotti, Keith R.; Boyle, Timothy P.; Heckaman, Charlotte L.; Bohanon, Michael J.; Tomich, Paul K.; Zurenko, Gary E.; Sweeney, Michael T.; Yagi, Betty H.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 14 p. 1903 - 1906
