1.1: 85 percent / aq. sodium carbonate / tetrahydrofuran / 18 h / 20 °C 2.1: tetrahydrofuran / 3 h / 20 °C 3.1: 51.0 g / (dimethylamino)pyridine / tetrahydrofuran / 20 °C 4.1: aq. NaOH / dioxane 4.2: 71 percent / aq. sodium carbonate / tetrahydrofuran / 18 h / 20 °C View Scheme

chloro-trimethyl-silane; lead (II) nitrate in dichloromethane

1.1: triethylamine / Inert atmosphere 2.1: pyridinium chlorochromate / Inert atmosphere 3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 3.2: 1.5 h / -78 - 0 °C / Inert atmosphere 4.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 3.33 h / 20 °C / Inert atmosphere 5.1: diethyl ether / 0.25 h / 0 °C / Inert atmosphere 6.1: toluene / 6 h / Inert atmosphere; Reflux 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere 8.1: lithium hydroxide hydrate / tetrahydrofuran / 1.5 h / Inert atmosphere 9.1: pyridine / toluene / 2.5 h / Inert atmosphere; Reflux 10.1: diethyl ether / 0.33 h / 0 °C / Inert atmosphere 11.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 20 °C / Inert atmosphere 12.1: Cu(I)CN / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 12.2: 0.75 h / -78 °C / Inert atmosphere 13.1: dimethylsulfide; oxygen; ozone / methanol; dichloromethane / 2 h / -116 - 20 °C / Inert atmosphere 14.1: diethyl ether / 0 °C / Inert atmosphere 15.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere 15.2: 1.5 h / -78 - 0 °C / Inert atmosphere 16.1: triethylsilane; tetrakis(triphenylphosphine) palladium(0); lithium chloride / N,N-dimethyl-formamide / 2 h / 55 °C / Inert atmosphere 17.1: lithium hydroxide hydrate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere 18.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 10 h / Inert atmosphere View Scheme

sodium carbonate T=0°C; 4 h;

1: 85 percent / N-methylmorpholine; 4-(dimethylamino)pyridine / dimethylformamide / 13 h / 55 °C 2: 72 percent / pyridine / 13 h View Scheme

暂无反应条件数据

triethylamine in tetrahydrofuran; water T=20°C;

triethylamine in tetrahydrofuran; water 12 h; Ambient temperature;

1: sodium hydrogencarbonate / methanol / 20 °C / |Inert atmosphere 2: lithium borohydride / tetrahydrofuran / 4 h / 20 °C / |Inert atmosphere View Scheme

1.1: 15.529 g / DMAP; Et3N / CH2Cl2 / Cooling 2.1: 78 percent / DMAP; Et3N / CH2Cl2 / 2 h / 0 °C 3.1: PhSeSePh; NaBH4 / methanol / 11 h / Heating 3.2: 63 percent / pyridine; H2O2 / CH2Cl2; H2O / 2 h / 20 °C View Scheme