5-氨基-1,3,4-噻二唑-2-磺酰胺合成路线 （共 14 条）
反应条件
hydrogenchloride in methanol; water 18 h; Reflux;
参考文献
Sequoia Sciences, Inc.; Eldridge, Gary R.; Buckle, Ronald Neil; Ellis, Michael; Huang, Zhongping; Reilly, John Edward
Patent: EP2712863 A1, 2014 ;
Location in patent: Paragraph 0567 ;
反应条件
sodium hydrogencarbonate in water pH=7;
参考文献
WO2004/76432 A1, ;
Page 47 ;
反应条件
water T=25°C; effect of pH (1.68 - 8.17), two buffer species (phosphate and citrate), ionic strength and temperature on stability of title compound; Ea; Thermodynamic data;
参考文献
Journal of pharmaceutical sciences, , vol. 78, # 10 p. 855 - 857
反应条件
sodium hydroxide; iodine; potassium iodide T=0 - 4°C;
参考文献
Supuran, Claudiu T; Briganti, Fabrizio; Tilli, Silvia; Chegwidden; Scozzafava, Andrea
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 703 - 714
反应条件
sodium hydroxide; sodium hypochlorite T=25 - 30°C;
参考文献
Supuran, Claudiu T; Briganti, Fabrizio; Tilli, Silvia; Chegwidden; Scozzafava, Andrea
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 703 - 714
反应条件
sodium hydroxide in water; acetone T=0 - 5°C;
参考文献
Xiao, Zhonghai; Duan, Ruifeng; Cui, Wenyu; Zhang, Yanfang; Zhang, Shouguo; Chen, Fangjin; Zhang, Yankun; Liu, Jiaying; Zhang, Dongxiang; Meng, Yuan; Wang, Lin; Wang, Hai
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3221 - 3228
参考文献
Vaughan et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 700
参考文献
Vaughan et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 700
反应条件
sodium hydroxide; sodium hypochlorite
T=25 - 30°C; thiocarbamylation;
参考文献
Scozzafava, Andrea; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1117 - 1120
反应条件
pyridine in acetic acid
1 h;
参考文献
Chernykh, V. P.; Buluda, Zh. P.; Bezuglyi, P. A.; Makurina, V. I.; Chubenko, V. A.; Voronina, L. N.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 2 p. 107 - 110
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 2 p. 33 - 37
