反应条件
1.1: N,N-dimethylcarbamoyl chloride / dichloromethane / 48 h / 20 °C / |Inert atmosphere
2.1: hydrogenchloride; palladium 10 on activated carbon; hydrogen / water; ethanol / 12 h / |Inert atmosphere
3.1: acetic anhydride / 3 h / 50 - 60 °C / |Inert atmosphere
3.2: 8 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;