R-(+)-2-甲基-1-苯基-1-丙醇合成路线 （共 41 条）
反应条件
1: AlPh3*THF With titanium(IV) isopropylate; C56H70N2O10S2Ti2 in tetrahydrofuran
T=0°C; 0.166667 h; Inert atmosphere;
2: isobutyraldehyde in tetrahydrofuran
T=0°C; 0.5 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Zhou, Shuangliu; Chuang, Da-Wei; Chang, Shih-Ju; Gau, Han-Mou
Tetrahedron Asymmetry, 2009 , vol. 20, # 12 p. 1407 - 1412
反应条件
(S,Rp)-[1-(2-bromoferrocenyl)ethyl]diphenylphosphine; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) in toluene
T=20°C; 24 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Suzuma, Yoshinori; Hayashi, Shoko; Yamamoto, Tetsuya; Oe, Yohei; Ohta, Tetsuo; Ito, Yoshihiko
Tetrahedron Asymmetry, 2009 , vol. 20, # 23 p. 2751 - 2758
反应条件
lithium aluminium tetrahydride in diethyl ether
6 h; Heating;
参考文献
Naemura, Koichiro; Murata, Masaki; Tanaka, Rie; Yano, Masashi; Hirose, Keiji; Tobe, Yoshito
Tetrahedron Asymmetry, 1996 , vol. 7, # 11 p. 3285 - 3294
反应条件
Birman's catalyst; trimethylacetic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 12 h; optical yield given as percent eeenantioselective reaction;
参考文献
Shiina, Isamu; Nakata, Kenya; Sugimoto, Masuhiro; Onda, Yu-Suke; Iizumi, Takashi; Ono, Keisuke
Heterocycles, 2009 , vol. 77, # 2 p. 801 - 810
反应条件
Multistep reaction. Title compound not separated from byproducts.;
参考文献
Stymiest, Jake L.; Dutheuil, Guillaume; Mahmood, Adeem; Aggarwal, Varinder K.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 39 p. 7491 - 7494
反应条件
methanol; sodium hydroxide; dihydrogen peroxide; (-)-Monoisopinocampheylborane
1.) THF, -25 deg C, 26 h, 2.) 55 deg C, 1 h; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Brown, Herbert C.; Jadhav, Prabhakar K.; Mandal, Arun K.
Journal of Organic Chemistry, 1982 , vol. 47, # 26 p. 5074 - 5083
反应条件
(1S,2R)-(-)-2-(N,N-di-n-butylamino)-1-phenylpropan-1-ol
1.) hexane, rt, 20 min 2.) hexane, 0 deg C, 16 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Soai, Kenso; Yokoyama, Shuji; Hayasaka, Tomoiki
Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4264 - 4268
反应条件
Bacillus megaterium; oxygen
T=30°C; Oxidation; hydroxylation; 17 h; Microbiological reaction; Product distribution; Further Variations:Reaction partnersCatalystsReagents;
参考文献
Adam, Waldemar; Lukacs, Zoltan; Harmsen, Dag; Saha-Moeller, Chantu R.; Schreier, Peter
Journal of Organic Chemistry, 2000 , vol. 65, # 3 p. 878 - 882
参考文献
Basavaiah; Raju
Synthetic Communications, 1991 , vol. 21, # 18-19 p. 1859 - 1863
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Soai, Kenso; Kawase, Yasuhiro; Oshio, Atsushi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 6 p. 1613 - 1615
