2-甲基-1-苯基-1H-苯并咪唑合成路线 （共 49 条）
反应条件
copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in acetonitrile
T=80°C; 2 h; Inert atmosphere;
参考文献
Baars, Hannah; Beyer, Astrid; Kohlhepp, Stefanie V.; Bolm, Carsten
Organic Letters, 2014 , vol. 16, # 2 p. 536 - 539
反应条件
dimethyl sulfoxide; 1-propanephosphonic acid cyclic anhydride in ethyl acetate
T=0 - 25°C; 4 h; Inert atmosphere; chemoselective reaction;
参考文献
Raghavendra, Goravanahalli M.; Ramesha, Ajjahalli B.; Revanna, Cigalli N.; Nandeesh, Kebbahalli N.; Mantelingu, Kempegowda; Rangappa, Kanchugarakoppal S.
Tetrahedron Letters, 2011 , vol. 52, # 43 p. 5571 - 5574
反应条件
copper(I) oxide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in water
T=100°C; 30 h; Sealed tube;
参考文献
Peng, Jinsong; Ye, Min; Zong, Cuijuan; Hu, Fangyun; Feng, Lingtong; Wang, Xiaoyan; Wang, Yufeng; Chen, Chunxia
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 716 - 719
反应条件
1: With potassium phosphate; N-methyl-1,2-ethanediamine; copper(l) iodide in toluene
T=100°C; 18 h;
2: With water in toluene
3: With iron; sodium hydrogencarbonate; acetic acid
Product distribution / selectivity; more than 3 stages;
参考文献
SANOFI-AVENTIS
Patent: WO2009/413 A1, 2008 ;
Location in patent: Page/Page column 26-27 ;
反应条件
N,N,N',N,-tetramethylethylenediamine; oxygen; copper(II) nitrate in methanol
T=20°C; P=760.051 Torr; 24 h;
参考文献
Wentzel, Michael T.; Hewgley, J. Brian; Kamble, Rajesh M.; Wall, Philip D.; Kozlowski, Marisa C.
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 6 p. 931 - 937
反应条件
1: With triethylamine in dichloromethane
T=20°C; 0.25 h; Inert atmosphere;
2: With methanesulfonyl chloride in dichloromethane
T=0 - 20°C; 5 h; Inert atmosphere;
参考文献
Wray, Brenda C.; Stambuli, James P.
Organic Letters, 2010 , vol. 12, # 20 p. 4576 - 4579
反应条件
palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; sodium t-butanolate in toluene
T=140°C; 24 h; Molecular sieveInert atmosphere; regiospecific reaction;
参考文献
Zhao, Dongbing; Hu, Junyi; Wu, Ningjie; Huang, Xiaolei; Qin, Xurong; Lan, Jingbo; You, Jingsong
Organic Letters, 2011 , vol. 13, # 24 p. 6516 - 6519
反应条件
(E,Z)-crotononitrile; palladium 10 on activated carbon in toluene
T=170°C; 1.5 h; Microwave irradiationInert atmosphere;
参考文献
De Luca, Lidia; Porcheddu, Andrea
European Journal of Organic Chemistry, 2011 , # 29 p. 5791 - 5795
反应条件
carbon monoxide; anhydrous lithium acetate; triphenylphosphine; ruthenium trichloride in various solvent(s)
T=180°C; 8 h;
参考文献
Spencer, Alwyn
Journal of Organometallic Chemistry, 1985 , vol. 295, p. 79 - 90
反应条件
carbon monoxide; anhydrous lithium acetate; triphenylphosphine; ruthenium trichloride in various solvent(s)
T=180°C; 8 h;
参考文献
Spencer, Alwyn
Journal of Organometallic Chemistry, 1985 , vol. 295, p. 79 - 90
