2-(3-羟基-丙基)-苯酚合成路线 （共 34 条）
反应条件
hydrogen; triphenylphosphine; [rhodium(I)(carbonyl)2(acetylacetonate)] in 1,4-dioxane
T=60°C; P=37503 Torr; 20 h;
参考文献
Roggenbuck, Rafael; Schmidt, Andreas; Eilbracht, Peter
Organic Letters, 2002 , vol. 4, # 2 p. 289 - 291
反应条件
hydrogen; triphenylphosphine in 1,4-dioxane
T=60°C;
参考文献
Roggenbuck, Rafael; Schmidt, Andreas; Eilbracht, Peter
Organic Letters, 2002 , vol. 4, # 2 p. 289 - 291
反应条件
ammonia; calcium in tetrahydrofuran
T=-33°C; 2 h; other reagents: lithium, sodium, liq. ammonia;
参考文献
Hwu, Jih Ru; Wein; Leu, Yi-Jing
Journal of Organic Chemistry, 1996 , vol. 61, # 4 p. 1493 - 1498
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
4 h; Heating;
参考文献
Yadav, Veejendra K; Ganesh Babu; Mittal, Manish
Tetrahedron, 2001 , vol. 57, # 32 p. 7047 - 7051
反应条件
phosphate buffer in diethyl ether
6 h; Ambient temperaturepig liver acetone powder;
参考文献
Basavaiah; Raju
Synthetic Communications, 1994 , vol. 24, # 4 p. 467 - 473
反应条件
1: 99 percent / hydrogen / Pd/C / ethanol / 1.5 h
2: 75 percent / K2CO3, KI / acetone / 12 h / Heating
3: 80 percent / 10percent aq. NaOH / methanol / 12 h
4: 1.) thionyl chloride / THF; 1.) reflux, 4 h; 2.) room temp., 12 h
5: 94 percent / hydrogen / Pd/C / ethanol / 8 h
6: acetonitrile; H2O / 50 °C / rate constants (kOH) for lactonization (buffered solution pH 10.0); other temp.: 70, 90 deg C
7: 91 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Amsberry, Kent L.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5867 - 5877
反应条件
1: 75 percent / K2CO3, KI / acetone / 12 h / Heating
2: 80 percent / 10percent aq. NaOH / methanol / 12 h
3: 1.) thionyl chloride / THF; 1.) reflux, 4 h; 2.) room temp., 12 h
4: 94 percent / hydrogen / Pd/C / ethanol / 8 h
5: acetonitrile; H2O / 50 °C / rate constants (kOH) for lactonization (buffered solution pH 10.0); other temp.: 70, 90 deg C
6: 91 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Amsberry, Kent L.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5867 - 5877
反应条件
1: 1.) thionyl chloride / THF; 1.) reflux, 4 h; 2.) room temp., 12 h
2: 94 percent / hydrogen / Pd/C / ethanol / 8 h
3: acetonitrile; H2O / 50 °C / rate constants (kOH) for lactonization (buffered solution pH 10.0); other temp.: 70, 90 deg C
4: 91 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Amsberry, Kent L.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5867 - 5877
反应条件
1: 80 percent / 10percent aq. NaOH / methanol / 12 h
2: 1.) thionyl chloride / THF; 1.) reflux, 4 h; 2.) room temp., 12 h
3: 94 percent / hydrogen / Pd/C / ethanol / 8 h
4: acetonitrile; H2O / 50 °C / rate constants (kOH) for lactonization (buffered solution pH 10.0); other temp.: 70, 90 deg C
5: 91 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Amsberry, Kent L.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5867 - 5877
反应条件
1: 94 percent / hydrogen / Pd/C / ethanol / 8 h
2: acetonitrile; H2O / 50 °C / rate constants (kOH) for lactonization (buffered solution pH 10.0); other temp.: 70, 90 deg C
3: 91 percent / lithium aluminum hydride / tetrahydrofuran
View Scheme
参考文献
Amsberry, Kent L.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5867 - 5877
