2-苯基-1H-喹啉-4-酮合成路线 （共 53 条）
反应条件
palladium on activated charcoal; copper(l) iodide; triethylamine in N,N-dimethyl-formamide
T=75 - 80°C; 3 h; Product distribution; Further Variations:ReagentsSolvents;
参考文献
Venkataraman, Subramanian; Barange, Deepak Kumar; Pal, Manojit
Tetrahedron Letters, 2006 , vol. 47, # 41 p. 7317 - 7322
反应条件
in diphenylether
T=250 - 260°C; 0.333333 h; Yield given;
参考文献
Chen, Bang-chi; Huang, Xian; Wang, Jin
Synthesis, 1987 , # 5 p. 482 - 483
反应条件
1: 95 percent / benzene / 48 h / Heating
2: 70 percent / LDA / tetrahydrofuran / 0 deg C to room temp., 8-12 h
View Scheme
参考文献
Chong, R.J.; Siddiqui, M.A.; Snieckus, V.
Tetrahedron Letters, 1986 , vol. 27, # 44 p. 5323 - 5326
反应条件
1: 95 percent / benzene / 48 h / Heating
2: 70 percent / LDA / tetrahydrofuran / 0 deg C to room temp., 8-12 h
View Scheme
参考文献
Chong, R.J.; Siddiqui, M.A.; Snieckus, V.
Tetrahedron Letters, 1986 , vol. 27, # 44 p. 5323 - 5326
反应条件
1: sodium hydroxide / methanol; water / 6 h / 20 °C
2: hydrogenchloride / water / 12 h / |Reflux
3: iodine / dimethyl sulfoxide / 12 h / 80 °C
View Scheme
参考文献
Dhiman, Rajni; Sharma, Sahil; Singh, Gagandip; Nepali, Kunal; Singh Bedi, Preet Mohinder
Archiv der Pharmazie, 2013 , vol. 346, # 1 p. 7 - 16
反应条件
1: pyridine / dichloromethane / 16 h / 20 °C
2: trimethylsilyl trifluoromethanesulfonate; triethylamine / 1,2-dichloro-ethane / 72 h / 95 °C / Inert atmosphere
View Scheme
参考文献
Eidamshaus, Christian; Triemer, Therese; Reissig, Hans-Ulrich
Synthesis, 2011 , # 20 art. no. T66411S, p. 3261 - 3266
反应条件
1: ethylene glycol dimethyl ether; diethyl ether / 1 h / 0 °C
2: 4-(N,N-dimethlyamino)pyridine / 6 h / 70 °C
3: sodium hydroxide / methanol; water / 6 h / 20 °C
4: hydrogenchloride / water / 12 h / |Reflux
5: iodine / dimethyl sulfoxide / 12 h / 80 °C
View Scheme
参考文献
Dhiman, Rajni; Sharma, Sahil; Singh, Gagandip; Nepali, Kunal; Singh Bedi, Preet Mohinder
Archiv der Pharmazie, 2013 , vol. 346, # 1 p. 7 - 16
反应条件
1: hydrogenchloride / water / 12 h / |Reflux
2: iodine / dimethyl sulfoxide / 12 h / 80 °C
View Scheme
参考文献
Dhiman, Rajni; Sharma, Sahil; Singh, Gagandip; Nepali, Kunal; Singh Bedi, Preet Mohinder
Archiv der Pharmazie, 2013 , vol. 346, # 1 p. 7 - 16
反应条件
sodium hydroxide
5 h; Heating;
参考文献
Tokes; Litkei; Szilagyi
Synthetic Communications, 1992 , vol. 22, # 17 p. 2433 - 2445
反应条件
1: 60 percent / 1.5 h / 650 °C
2: aq. methanol
View Scheme
参考文献
George, Lisa; Netsch, Klaus-Peter; Penn, Gerhard; Kollenz, Gert; Wentrup, Curt
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 3 p. 558 - 564
