3-溴-4-甲基苯甲酸乙酯合成路线 （共 9 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 168 h;
参考文献
Kubota, Katsumi; Kurebayashi, Hirotaka; Miyachi, Hirotaka; Tobe, Masanori; Onishi, Masako; Isobe, Yoshiaki
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 9 p. 3005 - 3021
反应条件
sulfuric acid in ethanol 22 h; Heating / reflux;
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1533304 A1, 2005 ;
Location in patent: Page/Page column 13 ;
EP 1533304 A1
反应条件
1: 86 percent / conc. HCl / benzene / 48 h / Heating 2: 100 percent / SnCl2*2H2O / ethanol / 0.5 h / 70 °C 3: 1.) aq. NaNO2, 48percent aq. HBr, 2.) CuBr, 48percent aq. HBr / 1.) -5 deg C, 5 min, 2.) 70 deg C, 1 h View Scheme
参考文献
Gilbert, Adam M.; Katz, Thomas J.; Geiger, William E.; Robben, Matthew P.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3199 - 3211
反应条件
1: 100 percent / SnCl2*2H2O / ethanol / 0.5 h / 70 °C 2: 1.) aq. NaNO2, 48percent aq. HBr, 2.) CuBr, 48percent aq. HBr / 1.) -5 deg C, 5 min, 2.) 70 deg C, 1 h View Scheme
参考文献
Gilbert, Adam M.; Katz, Thomas J.; Geiger, William E.; Robben, Matthew P.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3199 - 3211
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite 1.) -5 deg C, 5 min, 2.) 70 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Gilbert, Adam M.; Katz, Thomas J.; Geiger, William E.; Robben, Matthew P.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3199 - 3211
反应条件
sulfuric acid Heating;
参考文献
Zhao, Wen Jing; Shi, Yong Heng; Zhao, Gui Long; Wang, Yu Li; Shao, Hua; Da Tang, Li; Wang, Jian Wu
Chinese Chemical Letters, 2011 , vol. 22, # 10 p. 1215 - 1218
反应条件
sulfuric acid Heating;
参考文献
Zhang, Rui; Lei, Lin; Xu, Yun-Gen; Hua, Wei-Yi; Gong, Guo-Qing
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2430 - 2433
反应条件
1: N-bromosuccinimide / (PhCO)2O2 / CCl4 / Heating 2: K2CO3 / tetrahydrofuran / 20 °C 3: aq. NaOH / Heating View Scheme
参考文献
Asaki, Tetsuo; Sugiyama, Yukiteru; Hamamoto, Taisuke; Higashioka, Masaya; Umehara, Masato; Naito, Haruna; Niwa, Tomoko
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1421 - 1425
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
7 h; Reflux;
参考文献
Kubota, Katsumi; Kurebayashi, Hirotaka; Miyachi, Hirotaka; Tobe, Masanori; Onishi, Masako; Isobe, Yoshiaki
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 9 p. 3005 - 3021
