N-甲基磺酰基氨基甲酸叔丁酯合成路线 （共 7 条）
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane 2 h; Ambient temperature;
参考文献
Neustadt, Bernard R.
Tetrahedron Letters, 1994 , vol. 35, # 3 p. 379 - 380
反应条件
in dichloromethane 2.25 h;
参考文献
Eli Lilly and Company
Patent: US6358981 B1, 2002 ;
Location in patent: Page column 22 ;
US 6358981 B1
反应条件
n-butyllithium; potassium hydride 1) THF, hexane, -78 deg C, 30 min, 2) a) to r.t., 1 h, b) -78 deg C to r.t., 140 min, c) 45-50 deg C, 17 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 58, # 10 p. 2900 - 2903
反应条件
lithium diisopropyl amide 1) THF, hexane, -78 deg C, 6 min, 2) THF, a) -78 deg C, 105 min, b) to r.t., 105 min; Yield given. Multistep reaction;
参考文献
Campbell, Jeffrey A.; Hart, David J.
Journal of Organic Chemistry, 1993 , vol. 58, # 10 p. 2900 - 2903
反应条件
lithium diisopropyl amide 1) THF, hexane, -78 deg C, 6 min, 2) THF, a) -78 deg C, 105 min, b) to r.t., 105 min; Multistep reaction;
参考文献
Campbell, Jeffrey A.; Hart, David J.
Journal of Organic Chemistry, 1993 , vol. 58, # 10 p. 2900 - 2903
反应条件
1: 1) LDA / 1) THF, hexane, -78 deg C, 6 min, 2) THF, a) -78 deg C, 105 min, b) to r.t., 105 min 2: 100 percent / Ph3P, diethyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C 3: 94 percent / n-Bu4NF / tetrahydrofuran / 0.17 h View Scheme
参考文献
Campbell, Jeffrey A.; Hart, David J.
Journal of Organic Chemistry, 1993 , vol. 58, # 10 p. 2900 - 2903
反应条件
1: N-(t-butoxycarbonyl)methanesulfonamide With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; 0.133333 h;
2: chlorodiphenylphosphine oxide in tetrahydrofuran; hexane
T=-78°C; 1.5 h;
参考文献
Reuter, Deborah C.; McIntosh, Joel E.; Guinn, Ashley C.; Madera, Ann Marie
Synthesis, 2003 , # 15 p. 2321 - 2324
