乙基(3-硝基-2-氧代-1(2H)-吡啶基)乙酸酯合成路线 （共 3 条）
反应条件
1: 2-hydroxy-3-nitro-pyridine With sodium hydride in tetrahydrofuran 0.5 h; 2: ethyl bromoacetate in tetrahydrofuran T=55°C; 36 h; Further stages.;
参考文献
Karis, N. David; Loughlin, Wendy A.; Jenkins, Ian D.
Tetrahedron, 2007 , vol. 63, # 50 p. 12303 - 12309
反应条件
sodium hydride in N,N-dimethyl-formamide T=0°C; 3.5 h;
参考文献
COR Therapeutics, Inc.
Patent: US6369080 B2, 2002 ;
Location in patent: Example 4 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol 16 h;
参考文献
Corvas International, Inc.
Patent: US6342504 B1, 2002 ;
Location in patent: Page column 47 ;
US 6342504 B1
