5'-O-(4,4-二甲氧基三苯甲基)-2'-O-[(叔丁基)二甲基硅基]-N-异丁酰基鸟苷-3'-(2-氰基乙基-N,N-二异丙基)亚磷酰胺合成路线 (共 3 条)
反应条件
pyridinium trifluoroacetate in nitromethane T=20°C; 5 h;
参考文献
Zhang, Zhaoying; Gaffney, Barbara L.; Jones, Roger A.
Journal of the American Chemical Society, 2004 , vol. 126, # 51 p. 16700 - 16701
反应条件
N-ethyl-N,N-diisopropylamine 0.5 h; Ionic liquidball miling;
参考文献
Hardacre, Christopher; Huang, Haifeng; James, Stuart L.; Migaud, Marie E.; Norman, Sarah E.; Pitner, William R.
Chemical Communications, 2011 , vol. 47, # 20 p. 5846 - 5848
反应条件
1.1: N-ethyl-N,N-diisopropylamine; phosphorus trichoride / 0.5 h / Ionic liquid; Inert atmosphere 1.2: 0.67 h / Ionic liquid; Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine / 0.5 h / Ionic liquid; ball miling View Scheme
参考文献
Chemical Communications, , vol. 47, # 20 p. 5846 - 5848