4-氯-3-硝基苯甲酸甲酯合成路线 （共 40 条）
反应条件
1: 67.5 percent / dimethylformamide / 80 °C 2: 94 percent / H2 / Pd/C / ethanol / 2068.59 Torr View Scheme
参考文献
Oezden, Seckin; Atabey, Dilek; Yildiz, Sulhiye; Goeker, Hakan
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1587 - 1597
反应条件
sodium sulfide nonahydrate; sulfur in methanol; water T=55 - 65°C;
参考文献
Eastman Kodak Company
Patent: US2009/234131 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
hydrogen sulfide in methanol; methanol hydrate
参考文献
Walker, Daniel Patrick; Wishka, Donn G.; Corbett, Jeffrey W.; Rauckhorst, Mark R.; Piotrowski, David W.; Groppi JR., Vincent E.
Patent: US2003/73707 A1, 2003 ;
反应条件
sodium acetate in water; acetonitrile Heating / reflux; Product distribution / selectivity;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/69053 A1, 2007 ;
Location in patent: Page/Page column 33 ;
WO 2007/069053 A1
反应条件
ammonium cerium(IV) nitrate T=20°C; 144 h;
参考文献
Stefane, Bogdan; Kocevar, Marijan; Polanc, Slovenko
Synthetic Communications, 2002 , vol. 32, # 11 p. 1703 - 1707
反应条件
1: dimethylformamide / 80 °C 2: H2 / Pd/C / ethanol / 2068.59 Torr View Scheme
参考文献
Goeker, Hakan; Tebrizli, Emin; Abbasoglu, Ufuk
Farmaco, 1996 , vol. 51, # 1 p. 53 - 58
反应条件
1: 86 percent / bis(triphenylphosphine)palladium(II) chloride / triethylamine / 75 °C 2: 1.) KOH, 2.) acetic acid / 1.) 20 min, reflux 3: 99 percent / H2 / Pd/C / methanol; acetic acid / Ambient temperature 4: 97 percent / HCl / aq. HCl; ethanol / 0.5 h / 60 °C View Scheme
参考文献
Tischler, Allan N.; Lanza, Thomas J.
Tetrahedron Letters, 1986 , vol. 27, # 15 p. 1653 - 1656
反应条件
1: 17.6 g / Na2S*9H2O, S / ethanol; H2O / 3 h 2: 13.6 g / H2 / 10percent Pd/C / CH2Cl2 3: 70 percent / NaNO2, conc. HCl / H2O / 5 - 10 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 24 p. 4998 - 4999
反应条件
sodium tert-pentoxide in 1-methyl-pyrrolidin-2-one T=75°C; 1.5 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2009/71523 A1, 2009 ;
Location in patent: Page/Page column 6; 16-17 ;
反应条件
NH2NH2•xH2O in ethanol
8 h; Reflux;
参考文献
Hasan, Aurangzeb; Gapil, Shelly; Khan, Izzat
Asian Journal of Chemistry, 2011 , vol. 23, # 5 p. 2007 - 2010
