2,3,4,9-四氢-3-(甲基氨基)-1H-咔唑-6-甲酰胺合成路线 （共 4 条）
反应条件
1: With hydrogenchloride in water T=65 - 70°C; 2: With sodium hydroxide in water T=15°C; pH=10;
参考文献
ORCHID CHEMICALS AND PHARAMCEUTICALS LIMITED; REGURI, Buchi Reddy; UPPARAPALLI, Sampathkumar; KUNCHITHAPATHAM, Thirumurugan; SAMBASHIVAM, Thiyagarajan; MUNUSAMY, Suresh
Patent: WO2012/147020 A1, 2012 ;
Location in patent: Page/Page column 15 ;
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 1 h / -20 - 0 °C 1.2: Cooling 2.1: hydrogenchloride / water / 65 - 70 °C 2.2: 15 °C / pH 10 View Scheme
参考文献
ORCHID CHEMICALS AND PHARAMCEUTICALS LIMITED; REGURI, Buchi Reddy; UPPARAPALLI, Sampathkumar; KUNCHITHAPATHAM, Thirumurugan; SAMBASHIVAM, Thiyagarajan; MUNUSAMY, Suresh
Patent: WO2012/147020 A1, 2012 ;
反应条件
1.1: methanol 2.1: hydrogenchloride / water / 65 - 70 °C 2.2: 15 °C / pH 10 View Scheme
参考文献
ORCHID CHEMICALS AND PHARAMCEUTICALS LIMITED; REGURI, Buchi Reddy; UPPARAPALLI, Sampathkumar; KUNCHITHAPATHAM, Thirumurugan; SAMBASHIVAM, Thiyagarajan; MUNUSAMY, Suresh
Patent: WO2012/147020 A1, 2012 ;
反应条件
1.1: sulfuric acid / dichloromethane 2.1: methanol 3.1: hydrogenchloride / water / 65 - 70 °C 3.2: 15 °C / pH 10 View Scheme
参考文献
ORCHID CHEMICALS AND PHARAMCEUTICALS LIMITED; REGURI, Buchi Reddy; UPPARAPALLI, Sampathkumar; KUNCHITHAPATHAM, Thirumurugan; SAMBASHIVAM, Thiyagarajan; MUNUSAMY, Suresh
Patent: WO2012/147020 A1, 2012 ;
