5,6-二氢-1-苯并噻吩-7(4H)-酮合成路线 （共 15 条）
反应条件
thionyl chloride; pyridine in diethylene glycol dimethyl ether T=70°C; 24 h;
参考文献
Molino, Bruce F.; Liu, Shuang; Guzzo, Peter R.; Beck, James P.
Patent: US2006/52378 A1, 2006 ;
Location in patent: Page/Page column 148 ;
US 20060052378 A1
反应条件
in methanesulfonic acid
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US5739141 A1, 1998 ;
反应条件
ammonium cerium(IV) nitrate; acetic acid 0.5 h; Ambient temperature;
参考文献
Pinna, Gerard Aime; Pirisi, Maria Antonietta; Paglietti, Giuseppe
Journal of Chemical Research, Miniprint, 1993 , # 6 p. 1279 - 1296
反应条件
aluminium trichloride in carbon disulfide 3 h; Ambient temperature;
参考文献
Phosphorus and Sulfur and the Related Elements, , vol. 33, p. 25 - 32
反应条件
1: 95 percent / 98percent N2H4, KOH / bis-(2-hydroxy-ethyl) ether / 8 h / 180 °C 2: 72 percent / Ce(SO4)2 / aq. acetic acid / 1) -15 deg C, 2 h, 2) r.t., 2 h View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 33, # 11 p. 867 - 877
反应条件
1: 65 percent / H3PO4, Ac2O / 2.5 h / 120 °C 2: 95 percent / 98percent N2H4, KOH / bis-(2-hydroxy-ethyl) ether / 8 h / 180 °C 3: 72 percent / Ce(SO4)2 / aq. acetic acid / 1) -15 deg C, 2 h, 2) r.t., 2 h View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 33, # 11 p. 867 - 877
反应条件
1: 85 percent / 98percent N2H4, KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 180 °C 2: 65 percent / H3PO4, Ac2O / 2.5 h / 120 °C 3: 95 percent / 98percent N2H4, KOH / bis-(2-hydroxy-ethyl) ether / 8 h / 180 °C 4: 72 percent / Ce(SO4)2 / aq. acetic acid / 1) -15 deg C, 2 h, 2) r.t., 2 h View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 33, # 11 p. 867 - 877
反应条件
1: 98 percent / I2, Ph3P, imidazole / CH2Cl2 / 3 h / Ambient temperature 2: 1.) NaH / 1.) THF, 2.) THF, RT, 1 h 3: 96 percent / aq. KOH / ethanol / 7 h / Heating 4: 67 percent / bis-(2-hydroxy-ethyl) ether / 3 h 5: 70 percent / polyphosphoric acid / diethyl ether / 2 h / 120 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 3 p. 785 - 794
反应条件
1: 1.) NaH / 1.) THF, 2.) THF, RT, 1 h 2: 96 percent / aq. KOH / ethanol / 7 h / Heating 3: 67 percent / bis-(2-hydroxy-ethyl) ether / 3 h 4: 70 percent / polyphosphoric acid / diethyl ether / 2 h / 120 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 3 p. 785 - 794
反应条件
1: 67 percent / bis-(2-hydroxy-ethyl) ether / 3 h 2: 70 percent / polyphosphoric acid / diethyl ether / 2 h / 120 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 3 p. 785 - 794
