4-氨基-3-巯基苯甲酸合成路线 （共 17 条）
反应条件
sodium sulfide in ethanol; water T=90°C; 2 h;
参考文献
SANWA KAGAKU KENKYUSHO CO., LTD.
Patent: EP1595866 A1, 2005 ;
Location in patent: Page/Page column 25 ;
反应条件
1: With water; potassium hydroxide 24 h; Inert atmosphereReflux; 2: With hydrogenchloride in water Cooling with ice;
参考文献
Institute of Pharmacology and Toxicology Academy of Military Medical Science, P.L.A
Patent: US2011/319423 A1, 2011 ;
Location in patent: Page/Page column 10 ;
反应条件
1: Br2 / methanol / 2 h / -5 °C 2: 1N aq. HCl / Heating 3: KOH / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 1 p. 105 - 111
反应条件
sodium hydroxide 72 h; Heating;
参考文献
Charris, Jaime; Camacho, Jose; Ferrer, Rosa; Lobo, Gricela; Barazarte, Arthur; Gamboa, Neira; Rodrigues, Juan; Lopez, Simon
Journal of Chemical Research, 2006 , # 12 p. 769 - 770
反应条件
1: bromine / methanol / 2 h / -5 °C 2: hydrochloric acid / H2O / 0.5 h / Heating 3: potassium hydroxide / H2O / 4 h / Heating View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 35, # 5 p. 520 - 524
反应条件
1: 1N aq. HCl / Heating 2: KOH / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 1 p. 105 - 111
反应条件
1.1: acetic acid / 3.5 h / 20 °C / Cooling with ice 2.1: hydrogenchloride; water / 6 h / 100 °C 3.1: potassium hydroxide; water / 24 h / Inert atmosphere; Reflux 3.2: Cooling with ice View Scheme
参考文献
EP2354136 A1, ;
EP 2354136 A1
US2011/319423 A1, ;
反应条件
1.1: hydrogenchloride; water / 6 h / 100 °C 2.1: potassium hydroxide; water / 24 h / Inert atmosphere; Reflux 2.2: Cooling with ice View Scheme
参考文献
Rtishchev, N. I.; Kvitko, I. Ya.; Nagorskaya, L. P.; El'tsov, A. V.
Russian Journal of General Chemistry, 1993 , vol. 63, # 2.2 p. 303 - 309
Zhurnal Obshchei Khimii, 1993 , vol. 63, # 2 p. 429 - 438
反应条件
N,N-dimethyl-aniline 1.5 h; Heating;
参考文献
Burger,A.; Sawhney,S.N.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 270 - 273
