5-氯-N-甲基靛红酸酐合成路线 （共 15 条）
反应条件
oxygen; copper diacetate; palladium diacetate; potassium iodide; 2,2,2-trimethylacetic acid in acetonitrile T=60°C; P=760.051 Torr; regioselective reaction;
参考文献
Guan, Zheng-Hui; Chen, Ming; Ren, Zhi-Hui
Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17490 - 17493,4
反应条件
1: 6-chloro-2H-3,1-benzoxazine-2,4(1H)-dione With sodium hydride in N,N-dimethyl-formamide T=20°C; 1 h; 2: methyl bromide in N,N-dimethyl-formamide 18 h;
参考文献
Clark, Rachel L.; Clements, Carol J.; Barrett, Michael P.; MacKay, Simon P.; Rathnam, Rajendra P.; Owusu-Dapaah, George; Spencer, John; Huggan, Judith K.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 20 p. 6019 - 6033
反应条件
in ice-water; isobutyramide
参考文献
ALFA WASSERMANN S.p.A.
Patent: EP620210 A1, 1994 ;
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 17 p. 2427 - 2430
反应条件
1: H2SO4 / 80 °C 2: NaH / N,N-dimethyl-acetamide / 20 °C 3: mCPBA / CH2Cl2 / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 17 p. 2427 - 2430
反应条件
1: NaH / N,N-dimethyl-acetamide / 20 °C 2: mCPBA / CH2Cl2 / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 17 p. 2427 - 2430
反应条件
1: NH2OH*HCl; Na2SO4; aq. conc. HCl / Heating 2: H2SO4 / 80 °C 3: NaH / N,N-dimethyl-acetamide / 20 °C 4: mCPBA / CH2Cl2 / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 17 p. 2427 - 2430
反应条件
sodium hydride 1.) DMF, 2 h, 2.) 8 h; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 4 p. 1492 - 1503
反应条件
(i) aq. NaOH, (ii) /BRN= 385653/, (iii) AcCl; Multistep reaction;
参考文献
Journal of the Indian Chemical Society, , vol. 56, # 7 p. 708 - 711
反应条件
sodium hydride in N,N-dimethyl-formamide 1) 0-5 deg C, 15 min, 2) r.t. 18 h;
参考文献
Coppola, Gary M.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1785 - 1787
