[(1S,3S,4S)-4-氨基-3-羟基-5-苯基-1-(苯甲基)戊基]-氨基甲酸叔丁酯合成路线 （共 9 条）
反应条件
sodium hydrogencarbonate in water; ethyl acetate 0.5 h;
参考文献
US2005/131017 A1, ;
Page/Page column 98; 99 ;
反应条件
palladium dihydroxide; ammonium formate
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3101 - 3103
反应条件
1: Pd(OH)2; HCO2NH4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3101 - 3103
反应条件
1: Pd(OH)2; HCO2NH4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3101 - 3103
反应条件
1: in acetonitrile T=20°C; 0.333333 h; 2: With N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 48 h;
参考文献
GILEAD SCIENCES, INC.; CULLEN, Aaron, J.; YU, Richard, Hung Chiu
Patent: WO2013/116715 A1, 2013 ;
Location in patent: Page/Page column 70 ;
反应条件
in tetrahydrofuran; N,N-dimethyl-formamide T=20°C;
参考文献
Hamada, Yoshio; Ohtake, Jun; Sohma, Youhei; Kimura, Tooru; Hayashi, Yoshio; Kiso, Yoshiaki
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 12 p. 4155 - 4167
反应条件
1: EDC 2: trifluoroacetic acid View Scheme
参考文献
Sham, Hing L.; Zhao, Chen; Li, Leping; Betebenner, David A.; Saldivar, Ayda; Vasavanonda, Sudthida; Kempf, Dale J.; Plattner, Jacob J.; Norbeck, Daniel W.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3101 - 3103
反应条件
1: EDC 2: trifluoroacetic acid View Scheme
参考文献
Sham, Hing L.; Zhao, Chen; Li, Leping; Betebenner, David A.; Saldivar, Ayda; Vasavanonda, Sudthida; Kempf, Dale J.; Plattner, Jacob J.; Norbeck, Daniel W.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3101 - 3103
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide
参考文献
EP1170289 A2, ;
Page 41 ;
