3,3,5,5-四甲基环己酮合成路线 （共 36 条）
反应条件
triethylamine in chloroform 16 h; Heating;
参考文献
Still, Ian W. J.; Wilson, Donna Kaye T.
Canadian Journal of Chemistry, 1992 , vol. 70, # 3 p. 964 - 973
反应条件
in tetrahydrofuran; mineral oil
参考文献
Moebius, Hans-Joerg
Patent: US2004/87658 A1, 2004 ;
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 1.58 h / -78 - 0 °C 1.2: tetrahydrofuran; hexane / 4 h / -78 - 20 °C 2.1: 73 percent / AuCl3 / CH2Cl2; ethanol / 0.5 h / 20 °C View Scheme
参考文献
Engel, Douglas A.; Dudley, Gregory B.
Organic Letters, 2006 , vol. 8, # 18 p. 4027 - 4029
反应条件
hydrogen; Nic in ethanol T=25°C; P=760 Torr;
参考文献
Gallois, Philippe; Brunet, Jean-Jaques; Caubere, Paul
Journal of Organic Chemistry, 1980 , vol. 45, # 10 p. 1946 - 1950
反应条件
potassium hydroxide; hydroxylamine hydrochloride in water
参考文献
Gonzalez, Florenci; Sanz-Cervera, Juan F.; Williams, Robert M.
Tetrahedron Letters, 1999 , vol. 40, # 24 p. 4519 - 4522
反应条件
1: ammonium carbonate / aq. ethanol / 55 - 60 °C 2: aq. NaOH / 72 h / Heating View Scheme
参考文献
Palacin, Serge; Chin, Donovan N.; Simanek, Eric E.; MacDonald, John C.; Whitesides, George M.; McBride, Mary T.; Palmore, G. Tayhas R.
Journal of the American Chemical Society, 1997 , vol. 119, # 49 p. 11807 - 11816
反应条件
n-Pentyl nitrite; potassium hydride
1) DME, rt, 2) DME, -78 deg C to rt; Yield given. Multistep reaction;
参考文献
Elfehail. Fadia E.; Zajac, Walter W.
Journal of Organic Chemistry, 1981 , vol. 46, p. 5151 - 5155
反应条件
sodium azide; sulfuric acid in diethyl ether
3 h; Ambient temperature;
参考文献
Hutchison; Prager; Ward
Australian Journal of Chemistry, 1980 , vol. 33, # 11 p. 2477 - 2486
反应条件
1: acetic acid; bromine
2: aqueous KOH
View Scheme
参考文献
Sandris; Ourisson
Bulletin de la Societe Chimique de France, 1956 , p. 958,965
反应条件
1.1: tetrahydrofuran / 5 - 15 °C
2.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C
3.1: hydrogenchloride; thiourea / water / 6 h / Reflux
3.2: pH 7
4.1: ethyl acetate / 1 h / 0 - 5 °C
View Scheme
参考文献
MERZ PHARMA GMBH and CO. KGAA; KOLLER, Herbert; PYERIN, Michael; SBROGIO, Federico
Patent: WO2011/539 A1, 2011 ;
