1: 4-fluoro-3-methylanisol With N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
1 h; Heating / reflux;
2: sodium cyanide in ethanol; water
2.5 h; Heating / reflux;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/101528 A2, 2004 ;
Location in patent: Page 113 ;