3,5-二叔丁基-4-羟基苯甲酸合成路线 （共 48 条）
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Yohe et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 1289,1291
Journal of Organic Chemistry, 1959 , vol. 24, p. 1251,1256
参考文献
Zlobina,G.A.; Ershov,V.V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1964 , p. 1570 - 1577
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1964 , # 9 p. 1666 - 1675
反应条件
sulfuric acid Esterification; 216 h; Heating;
参考文献
Mandal, Subrata; Macikenas, Dainius; Protasiewicz, John D.; Sayre, Lawrence M.
Journal of Organic Chemistry, 2000 , vol. 65, # 16 p. 4804 - 4809
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane 2: lithium aluminium tetrahydride / tetrahydrofuran 3: trifluoroacetic acid / dichloromethane View Scheme
参考文献
Pajouhesh, Hassan; Feng, Zhong-Ping; Zhang, Lingyun; Pajouhesh, Hossein; Jiang, Xinpo; Hendricson, Adam; Dong, Haiheng; Tringham, Elizabeth; Ding, Yanbing; Vanderah, Todd W.; Porreca, Frank; Belardetti, Francesco; Zamponi, Gerald W.; Mitscher, Lester A.; Snutch, Terrance P.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4153 - 4158
反应条件
thionyl chloride; triethylamine in N-methyl-acetamide; methanol; dichloromethane
参考文献
The Green Cross Corporation
Patent: US5750545 A1, 1998 ;
反应条件
hydrogenchloride 10 h; Heating;
参考文献
Pastor, Stephen D.; Hessell, Edward T.
Journal of Organometallic Chemistry, 1987 , vol. 328, p. 263 - 274
参考文献
Mueller,E. et al.
Justus Liebigs Annalen der Chemie, 1961 , vol. 645, p. 36 - 52
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran T=20°C; 15 h;
参考文献
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6340700 B1, 2002 ;
Location in patent: Page column 20-21 ;
反应条件
1: thionyl chloride / hexane / Heating 2: 90 percent / toluene View Scheme
参考文献
Ivakhnenko, E. P.; Shif, A. I.; Prokof'ev, A. I.; Olekhnovich, L. P.; Minkin, V. I.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 2.2 p. 319 - 328
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 2 p. 357 - 367
反应条件
1: 84 percent / hydrogen chloride / 10 h / Heating 2: 1.) sodium hydride; 2.) 15-crown-5 / 1.) THF; 2.) THF, rt, 48 h 3: 6.52 g / 2.) tetraglyme / tetrahydrofuran / 1.) 55 deg C, 15 h; 2.) 78 deg C, 15 h View Scheme
参考文献
Snutch, Terrance P.; Zamponi, Gerald W.; Pajouhesh, Hassan; Belardetti, Francesco; Pajouhesh, Hossein
Patent: US2004/266784 A1, 2004 ;
US 20040266784 A1
