1: aq. H2SO4 2: NaBH4 View Scheme

sodium hydroxide; silver(l) oxide 8 h;

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 1.2: 1.5 h / -78 - 25 °C / Inert atmosphere 2.1: zirconocene dichloride; diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / 0 - 25 °C / Inert atmosphere 2.2: 0.5 h / -78 °C / Inert atmosphere 3.1: tetrakis(triphenylphosphine) palladium(0); copper(I) thiophene-2-carboxylate; [Ph2PO2]1-*[NBu4]1+ / N,N-dimethyl-formamide / 0.75 h / 25 °C / Inert atmosphere 4.1: manganese(IV) oxide; sodium carbonate / dichloromethane / 0.5 h / 0 - 25 °C / Inert atmosphere 5.1: sodium hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / 25 °C / Inert atmosphere 5.2: 2 h / -78 °C / Inert atmosphere 6.1: Grubb's 2nd generation catalyst / dichloromethane / 6.5 h / 50 °C / Inert atmosphere View Scheme

1: aq. H2SO4 View Scheme

application of the "prinzip of minimal chemical distance"; Mechanism;

1: AgNO3/NaOH / H2O; methanol / 0.75 h / 55 - 56 °C 2: H2, NaOCH3, NaClO4 / Rh-6 / methanol / 72 h / 1900 Torr / Ambient temperature; other: catalysts, temps., times, H2 pressures, solvents View Scheme

1: 92 percent / NaHMDS / tetrahydrofuran / 0 - 25 °C 2: 75 percent / 9-BBN; aq. H2O2; aq. NaOH / tetrahydrofuran / 0 °C 3: 85 percent / PPh3; I2; imidazole / toluene / 25 °C View Scheme

bis(cyclopentadienyl)titanium dichloride; zinc in tetrahydrofuran; water T=20°C; 6 h;

1: 93 percent / Ag2O, aq. NaOH / 8 h 2: 59 percent / 99percent HCO2H / 0.33 h / Heating 3: 68 percent / K2CO3 / acetone / 24 h / Ambient temperature View Scheme

tin; dihydrogen peroxide in various solvent(s) T=100°C; Baeyer-Villiger oxidation; 1 h; Product distribution; Further Variations:SolventsTemperaturesReagents;