2-氰基嘧啶合成路线

参考文献

ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;

14080-23-02-氰基嘧啶→90993-49-0N-羟基-2-嘧啶羧酰胺

参考文献

Ozcan, Sevil; Kazi, Aslamuzzaman; Marsilio, Frank; Fang, Bin; Guida, Wayne C.; Koomen, John; Lawrence, Harshani R.; Sebti, Said M.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 3783 - 3805

14080-23-02-氰基嘧啶→468067-81-4n-羟基-1-甲基-1H-咪唑-2-羧酰胺+90993-49-0N-羟基-2-嘧啶羧酰胺

参考文献

Bailey, Simon; Fish, Paul Vincent; James, Kim; Whitlock, Gavin Alistar
Patent: US2003/69291 A1, 2003 ;
US 20030069291 A1

14080-23-02-氰基嘧啶+95-54-51,2-苯二胺→18107-02-32-(2-嘧啶)-1H-苯并咪唑

参考文献

Haga, Masa-Aki; Ishizuya, Masahide; Kanesugi, Tomokazu; Yutaka, Tomona; Sakiyama, Daisuke; Fees, Joerg; Kaim, Wolfgang
Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, 2003 , vol. 42, # 9 p. 2290 - 2299

14080-23-02-氰基嘧啶→27427-92-52-嘧啶甲醛

参考文献

Lewandowska, Elzbieta; Chatfield, David C.
European Journal of Organic Chemistry, 2005 , # 15 p. 3297 - 3303

14080-23-02-氰基嘧啶→75985-45-42-甲胺基嘧啶

参考文献

THERACRINE, INC.; SUN, Lijun; BARSOUM, James; WESTER, Ronald
Patent: WO2013/13238 A2, 2013 ;
Location in patent: Page/Page column 42 ;

14080-23-02-氰基嘧啶+75-16-1甲基溴化镁→53342-27-12-乙酰基嘧啶

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/117051 A1, 2008 ;
Location in patent: Page/Page column 37 ;
WO 2008/117051 A1

14080-23-02-氰基嘧啶+917-64-6magnesium,carbanide,iodide→53342-27-12-乙酰基嘧啶

参考文献

Cibulka, Radek; Hampl, Frantisek; Martinu, Tomas; Mazac, Jiri; Totevova, Sonja; Liska, Frantisek
Collection of Czechoslovak Chemical Communications, 1999 , vol. 64, # 7 p. 1159 - 1179

14080-23-02-氰基嘧啶→54198-88-82-(氯甲基)嘧啶

参考文献

ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;

14080-23-02-氰基嘧啶+107-19-72-丙炔-1-醇→139584-77-32-丙炔-1-基2-嘧啶羧酸酯

参考文献

Stolle, Werner A. W.; Frissen, August E.; Marcelis, Antonius T. M.; Plas, Henk C. van der
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3000 - 3007