Trichogin A IV合成路线 （共 9 条）
反应条件
1: NMM
2: NMM
3: H2 / Pd/C
4: NMM
5: H2 / Pd/C
6: NMM
7: H2 / Pd/C
8: NMM
9: H2 / Pd/C
10: NMM
11: H2 / Pd/C
12: NMM
13: H2 / Pd/C
15: LiBH3 / tetrahydrofuran
View Scheme
参考文献
Toniolo; Crisma; Formaggio; Peggion; Monaco; Goulard; Rebuffat; Bodo
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 4952 - 4958
反应条件
1: NMM
2: H2 / Pd/C
3: NMM
4: H2 / Pd/C
5: NMM
6: H2 / Pd/C
7: NMM
8: H2 / Pd/C
9: NMM
10: H2 / Pd/C
11: NMM
12: H2 / Pd/C
14: LiBH3 / tetrahydrofuran
View Scheme
参考文献
Toniolo; Crisma; Formaggio; Peggion; Monaco; Goulard; Rebuffat; Bodo
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 4952 - 4958
反应条件
1: H2 / Pd/C
2: NMM
3: H2 / Pd/C
4: NMM
5: H2 / Pd/C
6: NMM
7: H2 / Pd/C
8: NMM
9: H2 / Pd/C
10: NMM
11: H2 / Pd/C
12: NMM
13: H2 / Pd/C
14: NMM
15: H2 / Pd/C
17: LiBH3 / tetrahydrofuran
View Scheme
参考文献
Toniolo; Crisma; Formaggio; Peggion; Monaco; Goulard; Rebuffat; Bodo
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 4952 - 4958
反应条件
1: NMM
2: H2 / Pd/C
3: NMM
4: H2 / Pd/C
5: NMM
6: H2 / Pd/C
7: NMM
8: H2 / Pd/C
10: LiBH3 / tetrahydrofuran
View Scheme
参考文献
Toniolo; Crisma; Formaggio; Peggion; Monaco; Goulard; Rebuffat; Bodo
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 4952 - 4958
反应条件
1: NMM
2: H2 / Pd/C
3: NMM
4: H2 / Pd/C
5: NMM
6: H2 / Pd/C
8: LiBH3 / tetrahydrofuran
View Scheme
参考文献
Toniolo; Crisma; Formaggio; Peggion; Monaco; Goulard; Rebuffat; Bodo
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 4952 - 4958
反应条件
1: H2 / Pd/C
3: LiBH3 / tetrahydrofuran
View Scheme
参考文献
Toniolo; Crisma; Formaggio; Peggion; Monaco; Goulard; Rebuffat; Bodo
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 4952 - 4958
反应条件
LiBH3 in tetrahydrofuran
参考文献
Toniolo; Crisma; Formaggio; Peggion; Monaco; Goulard; Rebuffat; Bodo
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 4952 - 4958
反应条件
2: LiBH3 / tetrahydrofuran
View Scheme
参考文献
Toniolo; Crisma; Formaggio; Peggion; Monaco; Goulard; Rebuffat; Bodo
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 4952 - 4958
反应条件
1: H-L-Lol-2-chlorotrityl resin; fmoc-L-Ile-OH With N-ethyl-N,N-diisopropylamine; HATU
1 h; solid phase reaction;
2: With piperidine in N,N-dimethyl-formamide
solid phase reaction;
3: octanoic acid; N-(9-fluorenylmethoxycarbonyl)glycine; N-Fmoc-L-leucine; Fmoc-(α-aminoisobutyric acid)
参考文献
De Zotti, Marta; Biondi, Barbara; Peggion, Cristina; Formaggio, Fernando; Park, Yoonkyung; Hahm, Kyung-Soo; Toniolo, Claudio
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 6 p. 1285 - 1299
