4-氧代-1,4-二氢-2,6-吡啶二甲酸合成路线 （共 41 条）
反应条件
in water T=20°C; Substitution; 48 h;
参考文献
Horvath, Gyoergy; Rusa, Cristian; Koentoes, Zoltan; Gerencser, Janos; Huszthy, Peter
Synthetic Communications, 1999 , vol. 29, # 21 p. 3719 - 3731
反应条件
1: 79 percent / BF3*Et2O / diethyl ether / 1.5 h / Ambient temperature 2: 85 percent / NaBH4 / methanol / 0 deg C to RT, 3 h 3: 1.) (COCl)2, 2.) Et3N / 1.) DMSO, CH2Cl2, -30 deg C, 20 min, 2.) -60 deg C, 25 min, then RT View Scheme
参考文献
Sugano; Kittaka; Otsuka; et al.
Tetrahedron Letters, 1986 , vol. 27, # 31 p. 3635 - 3638
反应条件
1: chelidamic acid With phosphorus pentachloride in chloroform Heating; 2: ethanol
参考文献
Labbe, Genevieve; Krismanich, Anthony P.; De Groot, Sarah; Rasmusson, Timothy; Shang, Muhong; Brown, Matthew D.R.; Dmitrienko, Gary I.; Guillemette, J. Guy
Journal of Inorganic Biochemistry, 2012 , vol. 112, p. 49 - 58
反应条件
1: With dichlorophenyl phosphine oxide T=120°C; 2 h; Inert atmosphere; 2: With water T=20°C; 1 h; Inert atmosphere;
参考文献
Renaud De La Faverie, Amandine; Hamon, Florian; Di Primo, Carmelo; Largy, Eric; Dausse, Eric; Delaurire, Laurence; Landras-Guetta, Corinne; Toulme, Jean-Jacques; Teulade-Fichou, Marie-Paule; Mergny, Jean-Louis
Biochimie, 2011 , vol. 93, # 8 p. 1357 - 1367
反应条件
1: chelidamic acid With phosphorus pentachloride in tetrachloromethane; water 15 h; Reflux; 2: methanol in tetrachloromethane; water 4 h; Reflux;
参考文献
Nakamura, Tatsuya; Mizukami, Shin; Tanaka, Miho; Kikuchi, Kazuya
Chemistry - An Asian Journal, 2013 , vol. 8, # 11 p. 2685 - 2690
反应条件
1: SOCl2 / dimethylformamide / 48 h / Heating View Scheme
参考文献
Bradshaw, J. S.; Maas, G. E.; Lamb, J. D.; Izatt, R. M.; Christensen J. J.
Journal of the American Chemical Society, 1980 , vol. 102, # 2 p. 467 - 474
反应条件
thionyl chloride 48 h; Heating;
参考文献
Rodriguez, Raphael; Mueller, Sebastian; Yeoman, Justin A.; Trentesaux, Chantal; Riou, Jean-Francois; Balasubramanian, Shankar
Journal of the American Chemical Society, 2008 , vol. 130, # 47 p. 15758 - 15759
反应条件
1: PCl5 / CHCl3 / Heating 3: 64 percent / NaBH4 / ethanol / 16 h / Heating View Scheme
参考文献
Kupai, Jozsef; Huszthy, Peter; Szekely, Kata; Toth, Tuende; Parkanyic, Laszlo
Arkivoc, 2011 , vol. 2011, # 9 p. 77 - 93
反应条件
1: potassium carbonate 2: ammonia / methanol 3: potassium hydroxide; bromine View Scheme
参考文献
Lou, Nan; Wang, Yangyang; Li, Haixia; Sokolov, Alexei P.; Xiong, Huiming
Polymer (United Kingdom), 2012 , vol. 53, # 20 p. 4455 - 4460
反应条件
sulfuric acid T=20°C; Reflux;
参考文献
Zeng, Tieqiang; Yang, Luo; Hudson, Reuben; Song, Gonghua; Moores, Audrey R.; Li, Chao-Jun
Organic Letters, 2011 , vol. 13, # 3 p. 442 - 445
