1-(2-噻吩基)-1-丙酮合成路线 （共 28 条）
反应条件
bromine; AlCl3, aluminium chloride in chloroform T=20°C; 17 h;
参考文献
Wyeth
Patent: US2007/4786 A1, 2007 ;
Location in patent: Page/Page column 39-40 ;
US 20070004786 A1
反应条件
hydrogenchloride; amalgamated zinc
参考文献
King; Nord
Journal of Organic Chemistry, 1949 , vol. 14, p. 638,639
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Profft
Chemiker-Zeitung, Chemische Apparatur, 1958 , vol. 82, p. 295,297
反应条件
1: alkaline permanganate
2: alkali; sodium amalgam
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参考文献
Ernst
Chemische Berichte, 1887 , vol. 20, p. 518
参考文献
Krekeler
Chemische Berichte, 1886 , vol. 19, p. 677
参考文献
Campaigne; Diedrich
Journal of the American Chemical Society, 1951 , vol. 73, p. 5240,5241
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=0°C; Vilsmeier-Haack Formylation; 0.5 h;
2: 1-(thien-2-yl)-1-propanone T=60 - 65°C; Vilsmeier-Haack Formylation; 5 h; Overall yield = 67 percent; Overall yield = 0.74 g;
参考文献
Kostyuchenko, Anastasia S.; Averkov, Alexey M.; Fisyuk, Alexander S.
Organic Letters, 2014 , vol. 16, # 7 p. 1833 - 1835
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=0°C; Vilsmeier-Haack Formylation; 0.5 h;
2: 1-(thien-2-yl)-1-propanone T=60 - 65°C; Vilsmeier-Haack Formylation; 5 h; Overall yield = 67 percent; Overall yield = 0.74 g;
参考文献
Kostyuchenko, Anastasia S.; Averkov, Alexey M.; Fisyuk, Alexander S.
Organic Letters, 2014 , vol. 16, # 7 p. 1833 - 1835
反应条件
T=180°C; anschliessendes Erwaermen mit wss. Natronlauge;
参考文献
Blicke; Burckhalter
Journal of the American Chemical Society, 1942 , vol. 64, p. 477,479
